Pharmacological Blockade of Cannabinoid CB1 Receptors in Diet-Induced Obesity Regulates Mitochondrial Dihydrolipoamide Dehydrogenase in Muscle

Cannabinoid CB1 receptors peripherally modulate energy metabolism. Here, we investigated the role of CB1 receptors in the expression of glucose/pyruvate/tricarboxylic acid (TCA) metabolism in rat abdominal muscle. Dihydrolipoamide dehydrogenase (DLD), a flavoprotein component (E3) of α-ketoacid dehy...

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Veröffentlicht in:	PloS one 2015-12, Vol.10 (12), p.e0145244-e0145244
Hauptverfasser:	Arrabal, Sergio, Lucena, Miguel Angel, Canduela, Miren Josune, Ramos-Uriarte, Almudena, Rivera, Patricia, Serrano, Antonia, Pavón, Francisco Javier, Decara, Juan, Vargas, Antonio, Baixeras, Elena, Martín-Rufián, Mercedes, Márquez, Javier, Fernández-Llébrez, Pedro, De Roos, Baukje, Grandes, Pedro, Rodríguez de Fonseca, Fernando, Suárez, Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bioenergetics Biosynthesis Body weight Body Weight - drug effects Cannabinoid CB1 receptors Carbohydrates Cell Line Dehydrogenase Dehydrogenases Diabetes Diet Dietary Carbohydrates Dihydrolipoamide Dehydrogenase - genetics Dihydrolipoamide Dehydrogenase - metabolism Down-regulation Electrophoresis, Gel, Two-Dimensional Energy Energy metabolism Enzymes Feeding Behavior - drug effects Food intake Gene expression Gene Expression Regulation - drug effects Glucose Glucose - metabolism Glucose isomerase Glutathione Glutathione reductase Glutathione Reductase - metabolism Glycolysis Homeostasis Insulin resistance L-Lactate dehydrogenase Lactate dehydrogenase Lactic acid Male Mass spectrometry Mass spectroscopy Metabolism Mice, Inbred C57BL Mitochondria Mitochondria - drug effects Mitochondria - enzymology Muscle Fibers, Skeletal - drug effects Muscle Fibers, Skeletal - enzymology Muscles Muscles - drug effects Muscles - enzymology Myotubes Neurosciences Obesity Obesity - enzymology Obesity - genetics Obesity - metabolism Overexpression Oxidation Oxidation-Reduction - drug effects Pharmacology Phosphates Phosphopyruvate hydratase Piperidines - pharmacology Pyrazoles - pharmacology Pyruvaldehyde Pyruvic acid Pyruvic Acid - metabolism Rats, Wistar Receptor, Cannabinoid, CB1 - metabolism Receptors Rodents Spectrometry, Mass, Electrospray Ionization Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Tricarboxylic acid cycle Triose-phosphate isomerase Weight control
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