Extracellular Protease Inhibition Alters the Phenotype of Chondrogenically Differentiating Human Mesenchymal Stem Cells (MSCs) in 3D Collagen Microspheres

Matrix remodeling of cells is highly regulated by proteases and their inhibitors. Nevertheless, how would the chondrogenesis of mesenchymal stem cells (MSCs) be affected, when the balance of the matrix remodeling is disturbed by inhibiting matrix proteases, is incompletely known. Using a previously...

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Veröffentlicht in:	PloS one 2016-01, Vol.11 (1), p.e0146928-e0146928
Hauptverfasser:	Han, Sejin, Li, Yuk Yin, Chan, Barbara Pui
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical materials Cartilage Cartilage - metabolism Cell Differentiation Chondrocytes - cytology Chondrogenesis Collagen Collagen (type I) Collagen (type II) Collagen - chemistry Collagen Type I - chemistry Collagen Type II - chemistry Dosage and administration Experiments Extracellular matrix Extracellular Matrix - metabolism Fibrocartilage - metabolism Gene expression Genetic aspects Humans Hydrogels Hydroxyproline - chemistry Immunohistochemistry Inhibition Laboratories Mechanical engineering Meniscus Mesenchymal stem cells Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - enzymology Mesenchyme Microencapsulation Microscopy, Fluorescence Microspheres Patient outcomes Penicillin Phenotype Physiological aspects Protease Protease inhibitors Protease Inhibitors - chemistry Proteinase inhibitors Real-Time Polymerase Chain Reaction Skin & tissue grafts Stem cells Tissue engineering Tissue Engineering - methods Tissue Scaffolds - chemistry Yang, Cindy
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