Inhibition of Hepatitis C Virus in Mice by a Small Interfering RNA Targeting a Highly Conserved Sequence in Viral IRES Pseudoknot

The hepatitis C virus (HCV) internal ribosome entry site (IRES) that directs cap-independent viral translation is a primary target for small interfering RNA (siRNA)-based HCV antiviral therapy. However, identification of potent siRNAs against HCV IRES by bioinformatics-based siRNA design is a challe...

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Veröffentlicht in:	PloS one 2016-01, Vol.11 (1), p.e0146710
Hauptverfasser:	Moon, Jae-Su, Lee, Seung-Hoon, Kim, Eun-Jung, Cho, Hee, Lee, Wooseong, Kim, Geon-Woo, Park, Hyun-Ji, Cho, Seung-Woo, Lee, Choongho, Oh, Jong-Won
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Antiviral activity Antiviral agents Antiviral Agents - chemistry Binding sites Bioinformatics Biotechnology Care and treatment Cell Survival Complications and side effects Computational Biology Conserved sequence Development and progression Disease Models, Animal Genomes Genomics Genotype Genotypes HEK293 Cells Hepacivirus - drug effects Hepacivirus - physiology Hepatitis Hepatitis C Hepatitis C - drug therapy Humans Interferon Internal ribosome entry site Internal Ribosome Entry Sites - genetics Liver diseases Mice Nanoparticles Nanoparticles - chemistry Neural networks Nucleotide sequence Nucleotides Nucleotides - chemistry Patient outcomes Phosphorothioate Plasmids Presenilin 1 Protein Structure, Tertiary Proteins Ribonucleic acid RNA RNA polymerase RNA, Small Interfering - chemistry RNA, Viral - chemistry RNA-mediated interference siRNA Therapy Tiling Transfection Virus Replication Viruses Xenografts
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