The Establishment of a Hyperactive Structure Allows the Tumour Suppressor Protein p53 to Function through P-TEFb during Limited CDK9 Kinase Inhibition

CDK9 is the catalytic subunit of positive elongation factor b (P-TEFb) that controls the transition of RNA polymerase II (RNAPII) into elongation. CDK9 inhibitors block mRNA synthesis and trigger activation of the stress-sensitive p53 protein. This in turn induces transcription of CDKN1A (p21) and o...

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Veröffentlicht in:	PloS one 2016-01, Vol.11 (1), p.e0146648-e0146648
Hauptverfasser:	Albert, Thomas K, Antrecht, Claudia, Kremmer, Elisabeth, Meisterernst, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Base Sequence Biology Catalysis Cell cycle Cell Line, Tumor Chemical synthesis Chromatin Immunoprecipitation Cyclin-dependent kinase 9 Cyclin-Dependent Kinase 9 - antagonists & inhibitors Cyclin-Dependent Kinase 9 - genetics Cyclin-Dependent Kinase 9 - metabolism Cyclin-dependent kinase inhibitor p21 Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Deoxyribonucleic acid DNA DNA-directed RNA polymerase Elongation Gene expression Gene silencing Genes Genetic aspects Genomes GTP-binding protein Health aspects HEK293 Cells HeLa Cells Humans Immunoglobulins Inhibition Inhibitors Kinases Laboratories MCF-7 Cells Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - genetics Nuclear Proteins - metabolism p53 Protein Phosphorylation Phosphotransferases Positive Transcriptional Elongation Factor B - metabolism Promoter Regions, Genetic Proteins Real-Time Polymerase Chain Reaction Ribonucleic acid RNA RNA Interference RNA polymerase RNA polymerase II RNA Polymerase II - metabolism RNA polymerases RNA, Small Interfering - metabolism Sequence Alignment Stem cells Transcriptional Activation Tumor proteins Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors
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