Downregulation of AKT3 Increases Migration and Metastasis in Triple Negative Breast Cancer Cells by Upregulating S100A4

Treatment of breast cancer patients with distant metastases represents one of the biggest challenges in today's gynecological oncology. Therefore, a better understanding of mechanisms promoting the development of metastases is of paramount importance. The serine/threonine kinase AKT was shown t...

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Veröffentlicht in:	PloS one 2016-01, Vol.11 (1), p.e0146370-e0146370
Hauptverfasser:	Grottke, Astrid, Ewald, Florian, Lange, Tobias, Nörz, Dominik, Herzberger, Christiane, Bach, Johanna, Grabinski, Nicole, Gräser, Lareen, Höppner, Frank, Nashan, Björn, Schumacher, Udo, Jücker, Manfred
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - secondary AKT protein AKT1 protein AKT2 protein Anatomy & physiology Animals Biochemistry Biology Biosynthesis Breast cancer Cancer Cancer metastasis Care and treatment Cell adhesion & migration Cell Line, Tumor Cell migration Cell Movement Chemotaxis Chemotaxis - genetics Depletion Diagnosis Diffusion Chambers, Culture Female Gene Expression Regulation, Neoplastic Gene Silencing Genomics Health aspects Humans In vivo methods and tests Isoforms Kinases Life assessment Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - secondary Medical prognosis Medicine Metastases Metastasis Mice MicroRNAs Morphology Motility Neoplasm Invasiveness Penicillin Physiology Protein-serine/threonine kinase Proteins Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Risk factors RNA, Small Interfering - genetics RNA, Small Interfering - metabolism S100 Calcium-Binding Protein A4 S100 Proteins - agonists S100 Proteins - genetics S100 Proteins - metabolism S100A4 protein Signal Transduction siRNA Threonine Transcription factors Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology Women Xenograft Model Antitumor Assays Xenografts Xenotransplantation
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