Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural Products

Due to the low structural diversity within the set of antimalarial drugs currently available in the clinic and the increasing number of cases of resistance, there is an urgent need to find new compounds with novel modes of action to treat the disease. Microbial natural products are characterized by...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2016-01, Vol.11 (1), p.e0145812-e0145812
Hauptverfasser:	Pérez-Moreno, Guiomar, Cantizani, Juan, Sánchez-Carrasco, Paula, Ruiz-Pérez, Luis Miguel, Martín, Jesús, El Aouad, Noureddine, Pérez-Victoria, Ignacio, Tormo, José Rubén, González-Menendez, Víctor, González, Ignacio, de Pedro, Nuria, Reyes, Fernando, Genilloud, Olga, Vicente, Francisca, González-Pacanowska, Dolores
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Antimalarial activity Antimalarial agents Antimalarials - chemistry Antimalarials - isolation & purification Antimalarials - pharmacology Antiprotozoal agents Biological Products - chemistry Biological Products - isolation & purification Biological Products - pharmacology Care and treatment Chemical compounds Chemistry Chromatography, High Pressure Liquid Collection Complications and side effects Databases, Factual Development and progression Drug Evaluation, Preclinical Drugs Erythrocytes High-throughput screening High-Throughput Screening Assays L-Lactate dehydrogenase L-Lactate Dehydrogenase - antagonists & inhibitors L-Lactate Dehydrogenase - metabolism Lactate dehydrogenase Lactic acid Malaria Mass Spectrometry Medical screening Microorganisms Natural products Optimization Parasites Patient outcomes Pepstatins - chemistry Pepstatins - pharmacology Pharmaceutical sciences Physiological aspects Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - enzymology Tropical diseases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!