Osteopontin That Is Elevated in the Airways during COPD Impairs the Antibacterial Activity of Common Innate Antibiotics

Bacterial infections of the respiratory tract contribute to exacerbations and disease progression in chronic obstructive pulmonary disease (COPD). There is also an increased risk of invasive pneumococcal disease in COPD. The underlying mechanisms are not fully understood but include impaired mucocil...

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Veröffentlicht in:	PloS one 2016-01, Vol.11 (1), p.e0146192-e0146192
Hauptverfasser:	Gela, Anele, Bhongir, Ravi K V, Mori, Michiko, Keenan, Paul, Mörgelin, Matthias, Erjefält, Jonas S, Herwald, Heiko, Egesten, Arne, Kasetty, Gopinath
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial activity Antibiotics Antimicrobial agents Bacteria Bacterial infections Bacterial Infections - complications Bacterial Infections - metabolism beta-Defensins - metabolism Binding Biocompatibility Biomedical materials Care and treatment Chemokines Chronic obstructive lung disease Chronic obstructive pulmonary disease Clinical Medicine Complications and side effects Cystic fibrosis Cytokines Cytokines - metabolism Elastase Glycoproteins Growth factors Haemophilus influenzae Health aspects Health risks Humans Immunoglobulins Infections Infectious diseases Inflammation Klinisk medicin Lactoferrin Lactoferrin - metabolism Leukocytes Lung - metabolism Lung diseases Lungmedicin och allergi Lysozyme Medical and Health Sciences Medicin och hälsovetenskap Medicine Midkine Molecular biology Neutrophils Obstructive lung disease Osteopontin Osteopontin - metabolism Peptidase Protein Binding Proteins Pseudomonas aeruginosa Pulmonary Disease, Chronic Obstructive - complications Pulmonary Disease, Chronic Obstructive - metabolism Pulmonary Disease, Chronic Obstructive - microbiology R&D Research & development Respiratory Medicine and Allergy Respiratory tract Respiratory tract diseases Respiratory Tract Infections - complications Respiratory Tract Infections - metabolism Respiratory Tract Infections - microbiology Risk factors Secretory Leukocyte Peptidase Inhibitor - metabolism Shielding Streptococcus infections Streptococcus pneumoniae Streptococcus pneumoniae - isolation & purification Thymic stromal lymphopoietin Thymus Treatment Failure Up-Regulation
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