The Combined Effect of Common Genetic Risk Variants on Circulating Lipoproteins Is Evident in Childhood: A Longitudinal Analysis of the Cardiovascular Risk in Young Finns Study

Low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) are modifiable risk factors for cardiovascular disease. Several genetic loci for predisposition to abnormal LDL-C, HDL-C and TG have been identified. However, it remains unclear whether...

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Veröffentlicht in:	PloS one 2016-01, Vol.11 (1), p.e0146081-e0146081
Hauptverfasser:	Buscot, Marie-jeanne, Magnussen, Costan G, Juonala, Markus, Pitkänen, Niina, Lehtimäki, Terho, Viikari, Jorma S A, Kähönen, Mika, Hutri-Kähönen, Nina, Schork, Nicholas J, Raitakari, Olli T, Thomson, Russell J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Adults Age Atherosclerosis Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - blood Cardiovascular Diseases - epidemiology Cardiovascular Diseases - genetics Care and treatment Child Child, Preschool Childhood Children Cholesterol Cholesterol, HDL - blood Cholesterol, HDL - genetics Cholesterol, LDL - blood Cholesterol, LDL - genetics Coronary vessels Data analysis Development and progression Disease prevention Divergence Female Finland - epidemiology Generalized linear models Genetic aspects Genetic factors Genetic Loci Genetic Predisposition to Disease Genetic Variation Genome-Wide Association Study Genomes Health risk assessment Health risks Heart High density lipoprotein Hospitals Humans Lipids Lipoproteins Lipoproteins (high density) Lipoproteins (low density) Loci Longitudinal Studies Low density lipoprotein Low density lipoproteins Male Males Medical research Medicine Middle Aged Obesity Pediatrics Polymorphism, Single Nucleotide Quartiles Risk analysis Risk factors Single nucleotide polymorphisms Single-nucleotide polymorphism Studies Trajectory analysis Triglycerides Triglycerides - blood Triglycerides - genetics Young Adult
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