Time-Course Analysis of Brain Regional Expression Network Responses to Chronic Intermittent Ethanol and Withdrawal: Implications for Mechanisms Underlying Excessive Ethanol Consumption

Long lasting abusive consumption, dependence, and withdrawal are characteristic features of alcohol use disorders (AUD). Mechanistically, persistent changes in gene expression are hypothesized to contribute to brain adaptations leading to ethanol toxicity and AUD. We employed repeated chronic interm...

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Veröffentlicht in:	PloS one 2016-01, Vol.11 (1), p.e0146257
Hauptverfasser:	Smith, Maren L, Lopez, Marcelo F, Archer, Kellie J, Wolen, Aaron R, Becker, Howard C, Miles, Michael F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Adaptations Addictions Alcohol Drinking - genetics Alcohol withdrawal delirium Alcoholic beverages Alcoholism Amygdala Analysis Animals Base Sequence Behavioral plasticity Behavioral sciences Bioinformatics Brain Brain - metabolism Brain research Brain-derived neurotrophic factor Care and treatment Central Nervous System Depressants - pharmacology Chromatin remodeling Computational Biology Computer programs Computer simulation Consumption Correlation analysis Cortex (temporal) DNA microarrays Dopamine Ethanol Ethanol - pharmacology Exposure Gene expression Gene Expression Profiling Gene Expression Regulation - drug effects Gene regulation Gene Regulatory Networks - drug effects Health aspects Inflammation Laboratory animals Linear Models Male Mesolimbic system Mice, Inbred C57BL MicroRNAs miRNA Models, Genetic Modules Network analysis Neurophysiology Neuroplasticity Neurosciences Oligonucleotide Array Sequence Analysis Physiological aspects Physiology Prefrontal cortex Psychiatry Regional analysis Risk factors Rodents Studies Substance Withdrawal Syndrome - genetics Temporal lobe Time Factors Toxicity Toxicology
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