Calcium Signaling Is Required for Erythroid Enucleation

Although erythroid enucleation, the property of erythroblasts to expel their nucleus, has been known for 7ore than a century, surprisingly little is known regarding the molecular mechanisms governing this unique developmental process. Here we show that similar to cytokinesis, nuclear extrusion requi...

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Veröffentlicht in:	PloS one 2016-01, Vol.11 (1), p.e0146201-e0146201
Hauptverfasser:	Wölwer, Christina B, Pase, Luke B, Russell, Sarah M, Humbert, Patrick O
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Blood Calcium Calcium (extracellular) Calcium (intracellular) Calcium - metabolism Calcium influx Calcium ions Calcium Signaling - physiology Calcium signalling Calcium-binding protein Calmodulin Calmodulin - metabolism Cancer Cell cycle Cell division Cell Nucleus - metabolism Cellular signal transduction Cytokinesis Enucleation Erythroblasts Erythroblasts - metabolism Erythropoiesis - physiology Experiments Extrusion Genetic aspects Genetics Immunoglobulins Intracellular signalling Kinases Mice Mice, Inbred C57BL Microscopy Molecular biology Molecular modelling Nuclei Oncology Phosphorylation Physiological aspects Proteins Red blood cells Signal transduction Transduction
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