The Gut Microbiome Is Altered in a Letrozole-Induced Mouse Model of Polycystic Ovary Syndrome
Women with polycystic ovary syndrome (PCOS) have reproductive and metabolic abnormalities that result in an increased risk of infertility, diabetes and cardiovascular disease. The large intestine contains a complex community of microorganisms (the gut microbiome) that is dysregulated in humans with...
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| Veröffentlicht in: | PloS one 2016-01, Vol.11 (1), p.e0146509-e0146509 |
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| creator | Kelley, Scott T Skarra, Danalea V Rivera, Alissa J Thackray, Varykina G |
| description | Women with polycystic ovary syndrome (PCOS) have reproductive and metabolic abnormalities that result in an increased risk of infertility, diabetes and cardiovascular disease. The large intestine contains a complex community of microorganisms (the gut microbiome) that is dysregulated in humans with obesity and type 2 diabetes. Using a letrozole-induced PCOS mouse model, we demonstrated significant diet-independent changes in the gut microbial community, suggesting that gut microbiome dysbiosis may also occur in PCOS women. Letrozole treatment was associated with a time-dependent shift in the gut microbiome and a substantial reduction in overall species and phylogenetic richness. Letrozole treatment also correlated with significant changes in the abundance of specific Bacteroidetes and Firmicutes previously implicated in other mouse models of metabolic disease in a time-dependent manner. Our results suggest that the hyperandrogenemia observed in PCOS may significantly alter the gut microbiome independently of diet. |
| doi_str_mv | 10.1371/journal.pone.0146509 |
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The large intestine contains a complex community of microorganisms (the gut microbiome) that is dysregulated in humans with obesity and type 2 diabetes. Using a letrozole-induced PCOS mouse model, we demonstrated significant diet-independent changes in the gut microbial community, suggesting that gut microbiome dysbiosis may also occur in PCOS women. Letrozole treatment was associated with a time-dependent shift in the gut microbiome and a substantial reduction in overall species and phylogenetic richness. Letrozole treatment also correlated with significant changes in the abundance of specific Bacteroidetes and Firmicutes previously implicated in other mouse models of metabolic disease in a time-dependent manner. Our results suggest that the hyperandrogenemia observed in PCOS may significantly alter the gut microbiome independently of diet.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0146509</identifier><identifier>PMID: 26731268</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abnormalities ; Animal models ; Animals ; Cardiovascular diseases ; Communities ; Complications and side effects ; Deoxyribonucleic acid ; Diabetes ; Diabetes mellitus ; Diet ; Digestive system ; Digestive tract ; Disease Models, Animal ; DNA ; Dysbacteriosis ; Feces ; Female ; Gastrointestinal Microbiome - physiology ; Gastrointestinal tract ; Genotype & phenotype ; Glucose ; Health risks ; Infertility ; Insulin resistance ; Intestinal microflora ; Laboratories ; Large intestine ; Letrozole ; Medicine ; Metabolic disorders ; Mice ; Microbiomes ; Microbiota ; Microbiota (Symbiotic organisms) ; Microorganisms ; Nitriles ; Obesity ; Phylogeny ; Physiological aspects ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - chemically induced ; Polycystic Ovary Syndrome - microbiology ; Reproductive health ; Rodents ; Studies ; Time dependence ; Triazoles ; Weight control</subject><ispartof>PloS one, 2016-01, Vol.11 (1), p.e0146509-e0146509</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Kelley et al. 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The large intestine contains a complex community of microorganisms (the gut microbiome) that is dysregulated in humans with obesity and type 2 diabetes. Using a letrozole-induced PCOS mouse model, we demonstrated significant diet-independent changes in the gut microbial community, suggesting that gut microbiome dysbiosis may also occur in PCOS women. Letrozole treatment was associated with a time-dependent shift in the gut microbiome and a substantial reduction in overall species and phylogenetic richness. Letrozole treatment also correlated with significant changes in the abundance of specific Bacteroidetes and Firmicutes previously implicated in other mouse models of metabolic disease in a time-dependent manner. Our results suggest that the hyperandrogenemia observed in PCOS may significantly alter the gut microbiome independently of diet.</description><subject>Abnormalities</subject><subject>Animal models</subject><subject>Animals</subject><subject>Cardiovascular diseases</subject><subject>Communities</subject><subject>Complications and side effects</subject><subject>Deoxyribonucleic acid</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diet</subject><subject>Digestive system</subject><subject>Digestive tract</subject><subject>Disease Models, Animal</subject><subject>DNA</subject><subject>Dysbacteriosis</subject><subject>Feces</subject><subject>Female</subject><subject>Gastrointestinal Microbiome - physiology</subject><subject>Gastrointestinal tract</subject><subject>Genotype & phenotype</subject><subject>Glucose</subject><subject>Health risks</subject><subject>Infertility</subject><subject>Insulin resistance</subject><subject>Intestinal microflora</subject><subject>Laboratories</subject><subject>Large intestine</subject><subject>Letrozole</subject><subject>Medicine</subject><subject>Metabolic disorders</subject><subject>Mice</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Microorganisms</subject><subject>Nitriles</subject><subject>Obesity</subject><subject>Phylogeny</subject><subject>Physiological aspects</subject><subject>Polycystic ovary syndrome</subject><subject>Polycystic Ovary Syndrome - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kelley, Scott T</au><au>Skarra, Danalea V</au><au>Rivera, Alissa J</au><au>Thackray, Varykina G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Gut Microbiome Is Altered in a Letrozole-Induced Mouse Model of Polycystic Ovary Syndrome</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-01-05</date><risdate>2016</risdate><volume>11</volume><issue>1</issue><spage>e0146509</spage><epage>e0146509</epage><pages>e0146509-e0146509</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Women with polycystic ovary syndrome (PCOS) have reproductive and metabolic abnormalities that result in an increased risk of infertility, diabetes and cardiovascular disease. The large intestine contains a complex community of microorganisms (the gut microbiome) that is dysregulated in humans with obesity and type 2 diabetes. Using a letrozole-induced PCOS mouse model, we demonstrated significant diet-independent changes in the gut microbial community, suggesting that gut microbiome dysbiosis may also occur in PCOS women. Letrozole treatment was associated with a time-dependent shift in the gut microbiome and a substantial reduction in overall species and phylogenetic richness. Letrozole treatment also correlated with significant changes in the abundance of specific Bacteroidetes and Firmicutes previously implicated in other mouse models of metabolic disease in a time-dependent manner. Our results suggest that the hyperandrogenemia observed in PCOS may significantly alter the gut microbiome independently of diet.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26731268</pmid><doi>10.1371/journal.pone.0146509</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Abnormalities Animal models Animals Cardiovascular diseases Communities Complications and side effects Deoxyribonucleic acid Diabetes Diabetes mellitus Diet Digestive system Digestive tract Disease Models, Animal DNA Dysbacteriosis Feces Female Gastrointestinal Microbiome - physiology Gastrointestinal tract Genotype & phenotype Glucose Health risks Infertility Insulin resistance Intestinal microflora Laboratories Large intestine Letrozole Medicine Metabolic disorders Mice Microbiomes Microbiota Microbiota (Symbiotic organisms) Microorganisms Nitriles Obesity Phylogeny Physiological aspects Polycystic ovary syndrome Polycystic Ovary Syndrome - chemically induced Polycystic Ovary Syndrome - microbiology Reproductive health Rodents Studies Time dependence Triazoles Weight control |
| title | The Gut Microbiome Is Altered in a Letrozole-Induced Mouse Model of Polycystic Ovary Syndrome |
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