Decreased Frequency of Intestinal Regulatory CD5+ B Cells in Colonic Inflammation

CD5+ B cells are a type of regulatory immune cells, though the involvement of this B cell subset in intestinal inflammation and immune regulation is not fully understood. We examined the distribution of CD5+ B cells in various mouse organs. Expression levels of CD11b, IgM, and toll-like receptor (TL...

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Veröffentlicht in:	PloS one 2016-01, Vol.11 (1), p.e0146191-e0146191
Hauptverfasser:	Mishima, Yoshiyuki, Ishihara, Shunji, Oka, Akihiko, Fukuba, Nobuhiko, Oshima, Naoki, Sonoyama, Hiroki, Yamashita, Noritsugu, Tada, Yasumasa, Kusunoki, Ryusaku, Moriyama, Ichiro, Yuki, Takafumi, Kawashima, Kousaku, Kinoshita, Yoshikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocyte Subsets - immunology B-Lymphocyte Subsets - metabolism CD11b antigen CD11b Antigen - analysis CD5 antigen CD5 Antigens - analysis Chronic Disease Colitis - chemically induced Colitis - immunology Colon Cytometry Dextran Dextran sulfate Dextran Sulfate - toxicity Flow cytometry Immune system Immunoglobulin M Immunoglobulin M - analysis Immunoregulation Inflammatory bowel disease Inflammatory bowel diseases Interleukin 10 Interleukin-10 - biosynthesis Intestinal Mucosa - immunology Intestinal Mucosa - pathology Intestine Lamina propria Lymphocytes B Male Mice Mice, Inbred BALB C Mucosa Organs Pathogenesis Proteins Rodents Sodium Specific Pathogen-Free Organisms Sulfate T cell receptors TLR9 protein Toll-Like Receptor 4 - analysis Toll-Like Receptor 9 - analysis Toll-like receptors
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