How to Capitalize on the Retest Effect in Future Trials on Huntington's Disease

The retest effect-improvement of performance on second exposure to a task-may impede the detection of cognitive decline in clinical trials for neurodegenerative diseases. We assessed the impact of the retest effect in Huntington's disease trials, and investigated its possible neutralization. We...

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Veröffentlicht in:	PloS one 2015-12, Vol.10 (12), p.e0145842-e0145842
Hauptverfasser:	Schramm, Catherine, Katsahian, Sandrine, Youssov, Katia, Démonet, Jean-François, Krystkowiak, Pierre, Supiot, Frédéric, Verny, Christophe, Cleret de Langavant, Laurent, Bachoud-Lévi, Anne-Catherine
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Algorithms Analysis Clinical trials Cognition Cognition & reasoning Cognitive ability Cognitive tasks Cohort Studies Discriminant analysis Disease Progression Female High definition television Humans Huntington Disease - physiopathology Huntington's disease Huntingtons disease Life Sciences Male Mathematical models Medical research Memory Methods Middle Aged Models, Statistical Nervous system diseases Neurodegenerative diseases Neurological diseases Neurology Neurons and Cognition Neurosciences Neutralization Patients Performance prediction Reproducibility of Results
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