Pretransplant HRCT Characteristics Are Associated with Worse Outcome of Lung Transplantation for Cystic Fibrosis Patients
Peri- and postoperative complications diminish the outcome of lung transplantation (LTx) in patients with cystic fibrosis (CF). We hypothesized that the degree of pathological findings on pre-LTx high resolution computed tomography (HRCT) is associated with higher morbidity and mortality in CF. All...
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| creator | Belle-van Meerkerk, Gerdien de Jong, Pim A de Valk, Harold W Neefjes, Tim Pameijer, Frank A Kwakkel-van Erp, Johanna M van de Graaf, Ed A |
| description | Peri- and postoperative complications diminish the outcome of lung transplantation (LTx) in patients with cystic fibrosis (CF). We hypothesized that the degree of pathological findings on pre-LTx high resolution computed tomography (HRCT) is associated with higher morbidity and mortality in CF.
All our CF patients undergoing LTx between 2001 and 2011 were included. HRCT examinations were evaluated according to a scoring system for pulmonary disease in CF patients, the Severe Advanced Lung Disease (SALD) score and for pleural involvement.
Fifty-three patients were included. Dominant infectious/inflammatory disease according to the SALD score was observed in 10 patients (19%). Five (50%) of those patients died within one week after LTx, compared to 2 (5%) patients without dominant infectious/inflammatory disease (p |
| doi_str_mv | 10.1371/journal.pone.0145597 |
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All our CF patients undergoing LTx between 2001 and 2011 were included. HRCT examinations were evaluated according to a scoring system for pulmonary disease in CF patients, the Severe Advanced Lung Disease (SALD) score and for pleural involvement.
Fifty-three patients were included. Dominant infectious/inflammatory disease according to the SALD score was observed in 10 patients (19%). Five (50%) of those patients died within one week after LTx, compared to 2 (5%) patients without dominant infectious/inflammatory disease (p<0.001). This difference in survival percentage remained also significant in multivariate analysis. Patients with infectious/inflammatory disease received more packed red blood cells; 26 versus 8 in the first week (p<0.001). Pleural thickening was associated with higher requirement (10 units) for blood transfusion during LTx, compared to patients with normal pleura (4 units).
The analysis of HRCT in CF patients according to the SALD score showed that dominant infectious/inflammatory disease is associated with a higher mortality after LTx. If confirmed in other studies, HRCT might aid estimation of surgical risk in some adult CF patients.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0145597</identifier><identifier>PMID: 26698308</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Blood ; Blood cells ; Blood transfusion ; Care and treatment ; CAT scans ; Complications ; Computed tomography ; Cystic fibrosis ; Cystic Fibrosis - diagnostic imaging ; Cystic Fibrosis - mortality ; Cystic Fibrosis - surgery ; Cysts ; Diabetes ; Erythrocytes ; Female ; Follow-Up Studies ; Forced Expiratory Volume ; Humans ; Infections ; Infectious diseases ; Internal medicine ; Lung - diagnostic imaging ; Lung - pathology ; Lung diseases ; Lung Transplantation ; Lungs ; Male ; Medicine ; Morbidity ; Mortality ; Multivariate Analysis ; Ostomy ; Patient outcomes ; Patients ; Pleura ; Pneumonia - diagnostic imaging ; Pneumonia - mortality ; Preoperative Period ; Prognosis ; Pseudomonas aeruginosa ; Respiratory Tract Infections - diagnostic imaging ; Respiratory Tract Infections - mortality ; Severity of Illness Index ; Surgery ; Survival Rate ; Thickening ; Tomography ; Tomography, X-Ray Computed - methods ; Transfusion ; Transplantation ; Transplants & implants ; Young Adult</subject><ispartof>PloS one, 2015-12, Vol.10 (12), p.e0145597-e0145597</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Belle-van Meerkerk et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Belle-van Meerkerk et al 2015 Belle-van Meerkerk et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-12a08a9131777cd77afa43fe79a049bbebea33d52546de0a84a13607b7041b73</citedby><cites>FETCH-LOGICAL-c692t-12a08a9131777cd77afa43fe79a049bbebea33d52546de0a84a13607b7041b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689402/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689402/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26698308$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Palaniyar, Nades</contributor><creatorcontrib>Belle-van Meerkerk, Gerdien</creatorcontrib><creatorcontrib>de Jong, Pim A</creatorcontrib><creatorcontrib>de Valk, Harold W</creatorcontrib><creatorcontrib>Neefjes, Tim</creatorcontrib><creatorcontrib>Pameijer, Frank A</creatorcontrib><creatorcontrib>Kwakkel-van Erp, Johanna M</creatorcontrib><creatorcontrib>van de Graaf, Ed A</creatorcontrib><title>Pretransplant HRCT Characteristics Are Associated with Worse Outcome of Lung Transplantation for Cystic Fibrosis Patients</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Peri- and postoperative complications diminish the outcome of lung transplantation (LTx) in patients with cystic fibrosis (CF). We hypothesized that the degree of pathological findings on pre-LTx high resolution computed tomography (HRCT) is associated with higher morbidity and mortality in CF.
All our CF patients undergoing LTx between 2001 and 2011 were included. HRCT examinations were evaluated according to a scoring system for pulmonary disease in CF patients, the Severe Advanced Lung Disease (SALD) score and for pleural involvement.
Fifty-three patients were included. Dominant infectious/inflammatory disease according to the SALD score was observed in 10 patients (19%). Five (50%) of those patients died within one week after LTx, compared to 2 (5%) patients without dominant infectious/inflammatory disease (p<0.001). This difference in survival percentage remained also significant in multivariate analysis. Patients with infectious/inflammatory disease received more packed red blood cells; 26 versus 8 in the first week (p<0.001). Pleural thickening was associated with higher requirement (10 units) for blood transfusion during LTx, compared to patients with normal pleura (4 units).
The analysis of HRCT in CF patients according to the SALD score showed that dominant infectious/inflammatory disease is associated with a higher mortality after LTx. If confirmed in other studies, HRCT might aid estimation of surgical risk in some adult CF patients.</description><subject>Adult</subject><subject>Blood</subject><subject>Blood cells</subject><subject>Blood transfusion</subject><subject>Care and treatment</subject><subject>CAT scans</subject><subject>Complications</subject><subject>Computed tomography</subject><subject>Cystic fibrosis</subject><subject>Cystic Fibrosis - diagnostic imaging</subject><subject>Cystic Fibrosis - mortality</subject><subject>Cystic Fibrosis - surgery</subject><subject>Cysts</subject><subject>Diabetes</subject><subject>Erythrocytes</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Forced Expiratory Volume</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Internal medicine</subject><subject>Lung - diagnostic imaging</subject><subject>Lung - pathology</subject><subject>Lung diseases</subject><subject>Lung Transplantation</subject><subject>Lungs</subject><subject>Male</subject><subject>Medicine</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Multivariate Analysis</subject><subject>Ostomy</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Pleura</subject><subject>Pneumonia - diagnostic imaging</subject><subject>Pneumonia - mortality</subject><subject>Preoperative Period</subject><subject>Prognosis</subject><subject>Pseudomonas aeruginosa</subject><subject>Respiratory Tract Infections - diagnostic imaging</subject><subject>Respiratory Tract Infections - mortality</subject><subject>Severity of Illness Index</subject><subject>Surgery</subject><subject>Survival Rate</subject><subject>Thickening</subject><subject>Tomography</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Transfusion</subject><subject>Transplantation</subject><subject>Transplants & implants</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk02P0zAQhiMEYpeFf4DAEhKCQ4u_4iQXpKpi2UqVuloqOFoTx2ldpXGxHaD_HnebrRq0B5SDE88zrzOvZ5LkNcFjwjLyaWM710Iz3tlWjzHhaVpkT5JLUjA6EhSzp2fvF8kL7zcYpywX4nlyQYUocobzy2R_63Rw0PpdA21AN3fTJZquwYEK2hkfjPJo4jSaeG-VgaAr9NuENfphnddo0QVltxrZGs27doWWJyUIxraotg5N9wcVdG1KZ73x6DaGdBv8y-RZDY3Xr_r1Kllef1lOb0bzxdfZdDIfKVHQMCIUcA4FYSTLMlVlGdTAWa2zAjAvylKXGhirUppyUWkMOQfCBM7KDHNSZuwqeXuU3TXWy940L0mWEp7TaEgkZkeisrCRO2e24PbSgpH3G9atJLhYQqOlUqVmPApTRTnEr1IrgjkvhcKCURG1PvendeVWVyoW6qAZiA4jrVnLlf0lucgLjmkU-NALOPuz0z7IrfFKN9FTbbv7_6ZpLmhKIvruH_Tx6npqBbEA09Y2nqsOonLCYzyNTZFGavwIFZ9Kb42KHVabuD9I-DhIiEzQf8IKOu_l7Nvd_7OL70P2_Rm71tCEtbdNd2gnPwT5EVSxrbzT9clkguVhQB7ckIcBkf2AxLQ35xd0SnqYCPYXEb4MJA</recordid><startdate>20151223</startdate><enddate>20151223</enddate><creator>Belle-van Meerkerk, Gerdien</creator><creator>de Jong, Pim A</creator><creator>de Valk, Harold W</creator><creator>Neefjes, Tim</creator><creator>Pameijer, Frank A</creator><creator>Kwakkel-van Erp, Johanna M</creator><creator>van de Graaf, Ed A</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20151223</creationdate><title>Pretransplant HRCT Characteristics Are Associated with Worse Outcome of Lung Transplantation for Cystic Fibrosis Patients</title><author>Belle-van Meerkerk, Gerdien ; de Jong, Pim A ; de Valk, Harold W ; Neefjes, Tim ; Pameijer, Frank A ; Kwakkel-van Erp, Johanna M ; van de Graaf, Ed A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-12a08a9131777cd77afa43fe79a049bbebea33d52546de0a84a13607b7041b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Blood</topic><topic>Blood cells</topic><topic>Blood transfusion</topic><topic>Care and treatment</topic><topic>CAT scans</topic><topic>Complications</topic><topic>Computed tomography</topic><topic>Cystic fibrosis</topic><topic>Cystic Fibrosis - diagnostic imaging</topic><topic>Cystic Fibrosis - mortality</topic><topic>Cystic Fibrosis - surgery</topic><topic>Cysts</topic><topic>Diabetes</topic><topic>Erythrocytes</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Forced Expiratory Volume</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Internal medicine</topic><topic>Lung - diagnostic imaging</topic><topic>Lung - pathology</topic><topic>Lung diseases</topic><topic>Lung Transplantation</topic><topic>Lungs</topic><topic>Male</topic><topic>Medicine</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Multivariate Analysis</topic><topic>Ostomy</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Pleura</topic><topic>Pneumonia - diagnostic imaging</topic><topic>Pneumonia - mortality</topic><topic>Preoperative Period</topic><topic>Prognosis</topic><topic>Pseudomonas aeruginosa</topic><topic>Respiratory Tract Infections - diagnostic imaging</topic><topic>Respiratory Tract Infections - mortality</topic><topic>Severity of Illness Index</topic><topic>Surgery</topic><topic>Survival Rate</topic><topic>Thickening</topic><topic>Tomography</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Transfusion</topic><topic>Transplantation</topic><topic>Transplants & implants</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Belle-van Meerkerk, Gerdien</creatorcontrib><creatorcontrib>de Jong, Pim A</creatorcontrib><creatorcontrib>de Valk, Harold W</creatorcontrib><creatorcontrib>Neefjes, Tim</creatorcontrib><creatorcontrib>Pameijer, Frank A</creatorcontrib><creatorcontrib>Kwakkel-van Erp, Johanna M</creatorcontrib><creatorcontrib>van de Graaf, Ed A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Belle-van Meerkerk, Gerdien</au><au>de Jong, Pim A</au><au>de Valk, Harold W</au><au>Neefjes, Tim</au><au>Pameijer, Frank A</au><au>Kwakkel-van Erp, Johanna M</au><au>van de Graaf, Ed A</au><au>Palaniyar, Nades</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pretransplant HRCT Characteristics Are Associated with Worse Outcome of Lung Transplantation for Cystic Fibrosis Patients</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-12-23</date><risdate>2015</risdate><volume>10</volume><issue>12</issue><spage>e0145597</spage><epage>e0145597</epage><pages>e0145597-e0145597</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Peri- and postoperative complications diminish the outcome of lung transplantation (LTx) in patients with cystic fibrosis (CF). We hypothesized that the degree of pathological findings on pre-LTx high resolution computed tomography (HRCT) is associated with higher morbidity and mortality in CF.
All our CF patients undergoing LTx between 2001 and 2011 were included. HRCT examinations were evaluated according to a scoring system for pulmonary disease in CF patients, the Severe Advanced Lung Disease (SALD) score and for pleural involvement.
Fifty-three patients were included. Dominant infectious/inflammatory disease according to the SALD score was observed in 10 patients (19%). Five (50%) of those patients died within one week after LTx, compared to 2 (5%) patients without dominant infectious/inflammatory disease (p<0.001). This difference in survival percentage remained also significant in multivariate analysis. Patients with infectious/inflammatory disease received more packed red blood cells; 26 versus 8 in the first week (p<0.001). Pleural thickening was associated with higher requirement (10 units) for blood transfusion during LTx, compared to patients with normal pleura (4 units).
The analysis of HRCT in CF patients according to the SALD score showed that dominant infectious/inflammatory disease is associated with a higher mortality after LTx. If confirmed in other studies, HRCT might aid estimation of surgical risk in some adult CF patients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26698308</pmid><doi>10.1371/journal.pone.0145597</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-12, Vol.10 (12), p.e0145597-e0145597 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1751482538 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Blood Blood cells Blood transfusion Care and treatment CAT scans Complications Computed tomography Cystic fibrosis Cystic Fibrosis - diagnostic imaging Cystic Fibrosis - mortality Cystic Fibrosis - surgery Cysts Diabetes Erythrocytes Female Follow-Up Studies Forced Expiratory Volume Humans Infections Infectious diseases Internal medicine Lung - diagnostic imaging Lung - pathology Lung diseases Lung Transplantation Lungs Male Medicine Morbidity Mortality Multivariate Analysis Ostomy Patient outcomes Patients Pleura Pneumonia - diagnostic imaging Pneumonia - mortality Preoperative Period Prognosis Pseudomonas aeruginosa Respiratory Tract Infections - diagnostic imaging Respiratory Tract Infections - mortality Severity of Illness Index Surgery Survival Rate Thickening Tomography Tomography, X-Ray Computed - methods Transfusion Transplantation Transplants & implants Young Adult |
| title | Pretransplant HRCT Characteristics Are Associated with Worse Outcome of Lung Transplantation for Cystic Fibrosis Patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T17%3A35%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pretransplant%20HRCT%20Characteristics%20Are%20Associated%20with%20Worse%20Outcome%20of%20Lung%20Transplantation%20for%20Cystic%20Fibrosis%20Patients&rft.jtitle=PloS%20one&rft.au=Belle-van%20Meerkerk,%20Gerdien&rft.date=2015-12-23&rft.volume=10&rft.issue=12&rft.spage=e0145597&rft.epage=e0145597&rft.pages=e0145597-e0145597&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0145597&rft_dat=%3Cgale_plos_%3EA438350535%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1751482538&rft_id=info:pmid/26698308&rft_galeid=A438350535&rft_doaj_id=oai_doaj_org_article_ccbe340412c24accbbec1044b6c06326&rfr_iscdi=true |