Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner
Berberine and its derivatives display potent analgesic, anti-inflammatory and anticancer activity. Here we aimed at characterizing the mechanism of action of berberine in the gastrointestinal (GI) tract and cortical neurons using animal models and in vitro tests. The effect of berberine was characte...
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| creator | Chen, Chunqiu Lu, Meiling Pan, Qiuhui Fichna, Jakub Zheng, Lijun Wang, Kesheng Yu, Zhen Li, Yongyu Li, Kun Song, Aihong Liu, Zhongchen Song, Zhenshun Kreis, Martin |
| description | Berberine and its derivatives display potent analgesic, anti-inflammatory and anticancer activity. Here we aimed at characterizing the mechanism of action of berberine in the gastrointestinal (GI) tract and cortical neurons using animal models and in vitro tests.
The effect of berberine was characterized in murine models mimicking diarrhea-predominant irritable bowel syndrome (IBS-D) symptoms. Then the opioid antagonists were used to identify the receptors involved. Furthermore, the effect of berberineon opioid receptors expression was established in the mouse intestine and rat fetal cortical neurons.
In mouse models, berberine prolonged GI transit and time to diarrhea in a dose-dependent manner, and significantly reduced visceral pain. In physiological conditions the effects of berberine were mediated by mu- (MOR) and delta- (DOR) opioid receptors; hypermotility, excessive secretion and nociception were reversed by berberine through MOR and DOR-dependent action. We also found that berberine increased the expression of MOR and DOR in the mouse bowel and rat fetal cortical neurons.
Berberine significantly improved IBS-D symptoms in animal models, possibly through mu- and delta- opioid receptors. Berberine may become a new drug candidate for the successful treatment of IBS-D in clinical conditions. |
| doi_str_mv | 10.1371/journal.pone.0145556 |
| format | Article |
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The effect of berberine was characterized in murine models mimicking diarrhea-predominant irritable bowel syndrome (IBS-D) symptoms. Then the opioid antagonists were used to identify the receptors involved. Furthermore, the effect of berberineon opioid receptors expression was established in the mouse intestine and rat fetal cortical neurons.
In mouse models, berberine prolonged GI transit and time to diarrhea in a dose-dependent manner, and significantly reduced visceral pain. In physiological conditions the effects of berberine were mediated by mu- (MOR) and delta- (DOR) opioid receptors; hypermotility, excessive secretion and nociception were reversed by berberine through MOR and DOR-dependent action. We also found that berberine increased the expression of MOR and DOR in the mouse bowel and rat fetal cortical neurons.
Berberine significantly improved IBS-D symptoms in animal models, possibly through mu- and delta- opioid receptors. Berberine may become a new drug candidate for the successful treatment of IBS-D in clinical conditions.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0145556</identifier><identifier>PMID: 26700862</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analgesics ; Animal models ; Animals ; Anticancer properties ; Antidepressants ; Antitumor activity ; Berberine ; Berberine - pharmacology ; Care and treatment ; Diarrhea ; Diarrhea - complications ; Diarrhea - drug therapy ; Disease Models, Animal ; Female ; Fetuses ; Gastrointestinal Motility - drug effects ; Gastrointestinal tract ; Health aspects ; Hospitals ; In vitro methods and tests ; Inflammation ; Intestinal motility ; Intestine ; Irritable bowel syndrome ; Irritable Bowel Syndrome - complications ; Irritable Bowel Syndrome - drug therapy ; Laboratory animals ; Male ; Medical research ; Medicine ; Mice ; Mice, Inbred BALB C ; Mimicry ; Motility ; Narcotics ; Neurons ; Opioid receptors (type delta) ; Opioid receptors (type mu) ; Pain ; Pain perception ; Physiological effects ; Physiology ; Rats ; Rats, Sprague-Dawley ; Real-Time Polymerase Chain Reaction ; Receptors ; Receptors, Opioid - genetics ; Receptors, Opioid - metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - genetics ; Rodents ; Secretion ; Visceral Pain - drug therapy ; Visceral Pain - etiology</subject><ispartof>PloS one, 2015-12, Vol.10 (12), p.e0145556-e0145556</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Chen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Chen et al 2015 Chen et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-3a8b9a5c18a6573e4a936d31a7773a8e0c21302974a7aea410087e4f147773463</citedby><cites>FETCH-LOGICAL-c692t-3a8b9a5c18a6573e4a936d31a7773a8e0c21302974a7aea410087e4f147773463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689480/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689480/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26700862$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Chunqiu</creatorcontrib><creatorcontrib>Lu, Meiling</creatorcontrib><creatorcontrib>Pan, Qiuhui</creatorcontrib><creatorcontrib>Fichna, Jakub</creatorcontrib><creatorcontrib>Zheng, Lijun</creatorcontrib><creatorcontrib>Wang, Kesheng</creatorcontrib><creatorcontrib>Yu, Zhen</creatorcontrib><creatorcontrib>Li, Yongyu</creatorcontrib><creatorcontrib>Li, Kun</creatorcontrib><creatorcontrib>Song, Aihong</creatorcontrib><creatorcontrib>Liu, Zhongchen</creatorcontrib><creatorcontrib>Song, Zhenshun</creatorcontrib><creatorcontrib>Kreis, Martin</creatorcontrib><title>Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Berberine and its derivatives display potent analgesic, anti-inflammatory and anticancer activity. Here we aimed at characterizing the mechanism of action of berberine in the gastrointestinal (GI) tract and cortical neurons using animal models and in vitro tests.
The effect of berberine was characterized in murine models mimicking diarrhea-predominant irritable bowel syndrome (IBS-D) symptoms. Then the opioid antagonists were used to identify the receptors involved. Furthermore, the effect of berberineon opioid receptors expression was established in the mouse intestine and rat fetal cortical neurons.
In mouse models, berberine prolonged GI transit and time to diarrhea in a dose-dependent manner, and significantly reduced visceral pain. In physiological conditions the effects of berberine were mediated by mu- (MOR) and delta- (DOR) opioid receptors; hypermotility, excessive secretion and nociception were reversed by berberine through MOR and DOR-dependent action. We also found that berberine increased the expression of MOR and DOR in the mouse bowel and rat fetal cortical neurons.
Berberine significantly improved IBS-D symptoms in animal models, possibly through mu- and delta- opioid receptors. Berberine may become a new drug candidate for the successful treatment of IBS-D in clinical conditions.</description><subject>Analgesics</subject><subject>Animal models</subject><subject>Animals</subject><subject>Anticancer properties</subject><subject>Antidepressants</subject><subject>Antitumor activity</subject><subject>Berberine</subject><subject>Berberine - pharmacology</subject><subject>Care and treatment</subject><subject>Diarrhea</subject><subject>Diarrhea - complications</subject><subject>Diarrhea - drug therapy</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Fetuses</subject><subject>Gastrointestinal Motility - drug effects</subject><subject>Gastrointestinal tract</subject><subject>Health aspects</subject><subject>Hospitals</subject><subject>In vitro methods and tests</subject><subject>Inflammation</subject><subject>Intestinal motility</subject><subject>Intestine</subject><subject>Irritable bowel syndrome</subject><subject>Irritable Bowel Syndrome - complications</subject><subject>Irritable Bowel Syndrome - drug therapy</subject><subject>Laboratory animals</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mimicry</subject><subject>Motility</subject><subject>Narcotics</subject><subject>Neurons</subject><subject>Opioid receptors (type delta)</subject><subject>Opioid receptors (type mu)</subject><subject>Pain</subject><subject>Pain perception</subject><subject>Physiological effects</subject><subject>Physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Receptors</subject><subject>Receptors, Opioid - genetics</subject><subject>Receptors, Opioid - metabolism</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - genetics</subject><subject>Rodents</subject><subject>Secretion</subject><subject>Visceral Pain - drug therapy</subject><subject>Visceral Pain - etiology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tu1DAQhiMEolB4AwSWkFB7kcWOHSe5QeqBQ6RWrVrorTWbTHZdEjvY3kLfjYfDoduqi3qBEiXR-Jt_MqckecXojPGCvb-0K2egn43W4Iwykee5fJQ8YxXPUplR_vje91by3PtLSnNeSvk02cpkQWkps2fJ7310c3TaIKmH0dkr9KQ2AX3QUZwc26B7Ha4JmJZcaN-gi9ZT0IbEOywxEis_PVvsPTnWg26-a7MghxqcWyKkpw5bO0QxE0jtnA4w75Hs25_Yk_Nr0zo7INmp98_Tw91oGMZgBz-JgyEno7a6Tc-wwWh25BBHNC1GpWMwBt2L5EkHvceX6_d28u3Tx68HX9Kjk8_1wd5R2sgqCymHcl5B3rASZF5wFFBx2XIGRVHEM6RNxjjNqkJAAQiCxdoUKDomJkBIvp28udEde-vVuvBesSJnosxEnkWiviFaC5dqdHoAd60saPXXYN1CgQu66VFRAdCVuaCNaISsaDUHKeYdSCyAZ3SK9mEdbTUfsG1ivrHoG6KbJ0Yv1cJeKSHLSpQ0CuysBZz9sYqtVMPUub4Hg7Fb039neSloWUX07T_ow9mtqQXEBLTpbIzbTKJqT_CS51RUZaRmD1DxajFORZzSTkf7hsPuhkNkAv4KC1h5r-rzs_9nTy422Xf32DiEfVh626-CtsZvguIGbJz13mF3V2RG1bRkt9VQ05Kp9ZJFt9f3G3TndLtV_A-INiK7</recordid><startdate>20151223</startdate><enddate>20151223</enddate><creator>Chen, Chunqiu</creator><creator>Lu, Meiling</creator><creator>Pan, Qiuhui</creator><creator>Fichna, Jakub</creator><creator>Zheng, Lijun</creator><creator>Wang, Kesheng</creator><creator>Yu, Zhen</creator><creator>Li, Yongyu</creator><creator>Li, Kun</creator><creator>Song, Aihong</creator><creator>Liu, Zhongchen</creator><creator>Song, Zhenshun</creator><creator>Kreis, Martin</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20151223</creationdate><title>Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner</title><author>Chen, Chunqiu ; Lu, Meiling ; Pan, Qiuhui ; Fichna, Jakub ; Zheng, Lijun ; Wang, Kesheng ; Yu, Zhen ; Li, Yongyu ; Li, Kun ; Song, Aihong ; Liu, Zhongchen ; Song, Zhenshun ; Kreis, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-3a8b9a5c18a6573e4a936d31a7773a8e0c21302974a7aea410087e4f147773463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Analgesics</topic><topic>Animal models</topic><topic>Animals</topic><topic>Anticancer properties</topic><topic>Antidepressants</topic><topic>Antitumor activity</topic><topic>Berberine</topic><topic>Berberine - pharmacology</topic><topic>Care and treatment</topic><topic>Diarrhea</topic><topic>Diarrhea - complications</topic><topic>Diarrhea - drug therapy</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Fetuses</topic><topic>Gastrointestinal Motility - drug effects</topic><topic>Gastrointestinal tract</topic><topic>Health aspects</topic><topic>Hospitals</topic><topic>In vitro methods and tests</topic><topic>Inflammation</topic><topic>Intestinal motility</topic><topic>Intestine</topic><topic>Irritable bowel syndrome</topic><topic>Irritable Bowel Syndrome - complications</topic><topic>Irritable Bowel Syndrome - drug therapy</topic><topic>Laboratory animals</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mimicry</topic><topic>Motility</topic><topic>Narcotics</topic><topic>Neurons</topic><topic>Opioid receptors (type delta)</topic><topic>Opioid receptors (type mu)</topic><topic>Pain</topic><topic>Pain perception</topic><topic>Physiological effects</topic><topic>Physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Receptors</topic><topic>Receptors, Opioid - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Chunqiu</au><au>Lu, Meiling</au><au>Pan, Qiuhui</au><au>Fichna, Jakub</au><au>Zheng, Lijun</au><au>Wang, Kesheng</au><au>Yu, Zhen</au><au>Li, Yongyu</au><au>Li, Kun</au><au>Song, Aihong</au><au>Liu, Zhongchen</au><au>Song, Zhenshun</au><au>Kreis, Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-12-23</date><risdate>2015</risdate><volume>10</volume><issue>12</issue><spage>e0145556</spage><epage>e0145556</epage><pages>e0145556-e0145556</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Berberine and its derivatives display potent analgesic, anti-inflammatory and anticancer activity. Here we aimed at characterizing the mechanism of action of berberine in the gastrointestinal (GI) tract and cortical neurons using animal models and in vitro tests.
The effect of berberine was characterized in murine models mimicking diarrhea-predominant irritable bowel syndrome (IBS-D) symptoms. Then the opioid antagonists were used to identify the receptors involved. Furthermore, the effect of berberineon opioid receptors expression was established in the mouse intestine and rat fetal cortical neurons.
In mouse models, berberine prolonged GI transit and time to diarrhea in a dose-dependent manner, and significantly reduced visceral pain. In physiological conditions the effects of berberine were mediated by mu- (MOR) and delta- (DOR) opioid receptors; hypermotility, excessive secretion and nociception were reversed by berberine through MOR and DOR-dependent action. We also found that berberine increased the expression of MOR and DOR in the mouse bowel and rat fetal cortical neurons.
Berberine significantly improved IBS-D symptoms in animal models, possibly through mu- and delta- opioid receptors. Berberine may become a new drug candidate for the successful treatment of IBS-D in clinical conditions.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26700862</pmid><doi>10.1371/journal.pone.0145556</doi><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1751482452 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Analgesics Animal models Animals Anticancer properties Antidepressants Antitumor activity Berberine Berberine - pharmacology Care and treatment Diarrhea Diarrhea - complications Diarrhea - drug therapy Disease Models, Animal Female Fetuses Gastrointestinal Motility - drug effects Gastrointestinal tract Health aspects Hospitals In vitro methods and tests Inflammation Intestinal motility Intestine Irritable bowel syndrome Irritable Bowel Syndrome - complications Irritable Bowel Syndrome - drug therapy Laboratory animals Male Medical research Medicine Mice Mice, Inbred BALB C Mimicry Motility Narcotics Neurons Opioid receptors (type delta) Opioid receptors (type mu) Pain Pain perception Physiological effects Physiology Rats Rats, Sprague-Dawley Real-Time Polymerase Chain Reaction Receptors Receptors, Opioid - genetics Receptors, Opioid - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Rodents Secretion Visceral Pain - drug therapy Visceral Pain - etiology |
| title | Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T01%3A00%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Berberine%20Improves%20Intestinal%20Motility%20and%20Visceral%20Pain%20in%20the%20Mouse%20Models%20Mimicking%20Diarrhea-Predominant%20Irritable%20Bowel%20Syndrome%20(IBS-D)%20Symptoms%20in%20an%20Opioid-Receptor%20Dependent%20Manner&rft.jtitle=PloS%20one&rft.au=Chen,%20Chunqiu&rft.date=2015-12-23&rft.volume=10&rft.issue=12&rft.spage=e0145556&rft.epage=e0145556&rft.pages=e0145556-e0145556&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0145556&rft_dat=%3Cgale_plos_%3EA438350498%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1751482452&rft_id=info:pmid/26700862&rft_galeid=A438350498&rft_doaj_id=oai_doaj_org_article_04aaf8540c4c46909ba64bfa6e7a3206&rfr_iscdi=true |