(R)-NODAGA-PSMA: A Versatile Precursor for Radiometal Labeling and Nuclear Imaging of PSMA-Positive Tumors

The present study aims at developing and evaluating an urea-based prostate specific membrane antigen (PSMA) inhibitor suitable for labeling with 111In for SPECT and intraoperative applications as well as 68Ga and 64Cu for PET imaging. The PSMA-based inhibitor-lysine-urea-glutamate-coupled to the spa...

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Veröffentlicht in:	PloS one 2015-12, Vol.10 (12), p.e0145755-e0145755
Hauptverfasser:	Gourni, Eleni, Canovas, Coline, Goncalves, Victor, Denat, Franck, Meyer, Philipp T, Maecke, Helmut R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - chemistry Acetates - metabolism Animal tissues Animals Antigens Antigens, Surface - metabolism Care and treatment Cytokinins Diagnostic imaging Ethylenediamine Ethylenediamines Female Gallium Radioisotopes - pharmacokinetics Glutamate Glutamate Carboxypeptidase II - metabolism Heterocyclic Compounds, 1-Ring - chemistry Heterocyclic Compounds, 1-Ring - metabolism Humans Image acquisition Image Processing, Computer-Assisted In vivo methods and tests Incubation Inhibitors Internalization Kidneys Labeling Labelling Ligands Lysine Male Medical imaging Medical research Metastasis Mice Mice, Inbred BALB C Nuclear medicine Penicillin Positron emission Positron-Emission Tomography Precursors Prostate Prostate cancer Prostatic Neoplasms - diagnostic imaging Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Radiochemistry Radiopharmaceuticals - pharmacokinetics Risk factors Single photon emission computed tomography Tissue Distribution Tomography Tumor Cells, Cultured Tumors Urea Xenograft Model Antitumor Assays Xenografts
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