The Insulin-Like Growth Factor System in the Long-Lived Naked Mole-Rat

Naked mole-rats (Heterocephalus glaber) (NMRs) are the longest living rodents known. They show negligible senescence, and are resistant to cancers and certain damaging effects associated with aging. The insulin-like growth factors (IGFs) have pluripotent actions, influencing growth processes in virt...

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Veröffentlicht in:	PloS one 2015-12, Vol.10 (12), p.e0145587-e0145587
Hauptverfasser:	Brohus, Malene, Gorbunova, Vera, Faulkes, Chris G, Overgaard, Michael T, Conover, Cheryl A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging (Biology) Aging - genetics Animals Bioavailability Cancer Cell cycle Cell survival Cellular signal transduction Endocrinology Female Gene expression Gene sequencing Genetic aspects Genomes Growth factors Humans Insulin Insulin-Like Growth Factor Binding Protein 4 - genetics Insulin-Like Growth Factor Binding Protein 5 - genetics Insulin-like growth factor I Insulin-like growth factor-binding protein 4 Insulin-like growth factor-binding protein 5 Insulin-like growth factors Life span Male Mice Mole Rats Molecular modelling Nucleotide sequence Physiological aspects Physiology Pluripotency Pregnancy Pregnancy-Associated Plasma Protein-A - genetics Protease Proteinase Proteins Proteolysis Rats Receptors Regulatory mechanisms (biology) Rodents Senescence Signaling Somatomedins - genetics Species Specificity Studies
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