Chemogenomic Study of Carboplatin in Saccharomyces cerevisiae: Inhibition of the NEDDylation Process Overcomes Cellular Resistance Mediated by HuR and Cullin Proteins

The use of carboplatin in cancer chemotherapy is limited by the emergence of drug resistance. To understand the molecular basis for this resistance, a chemogenomic screen was performed in 53 yeast mutants that had previously presented strong sensitivity to this widely used anticancer agent. Thirty-f...

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Veröffentlicht in:	PloS one 2015-12, Vol.10 (12), p.e0145377-e0145377
Hauptverfasser:	de Sousa, Graziele Fonseca, Lima, Maira de Assis, Custodio, Débora Fernandes, Freitas, Vanessa Morais, Monteiro, Gisele
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Antigens Aquaporins Baking yeast Cancer Cancer therapies Carboplatin Carboplatin - pharmacology Cell adhesion & migration Cell Line, Tumor - drug effects Chemotherapy Chromosomes, Human, Pair 1 Coding Complications and side effects Cullin Cullin Proteins - genetics Cullin Proteins - metabolism Cyclopentanes - pharmacology Datasets Defects Dosage and administration Drug resistance Drug Resistance, Fungal - drug effects Drug Resistance, Fungal - physiology Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics ELAV-Like Protein 1 - genetics ELAV-Like Protein 1 - metabolism Female Gene expression Gene Expression Profiling Genes Genetic aspects Genomes Homology Humans HuR protein Hypotheses Inhibition Medical prognosis mRNA Mutants Mutation Ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Physiological aspects Post-translation Proteins Pyrimidines - pharmacology Saccharomyces cerevisiae Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - genetics Scaffolds Tumors Ubiquitin Ubiquitin-Activating Enzymes - antagonists & inhibitors Ubiquitin-Activating Enzymes - genetics Ubiquitin-Activating Enzymes - metabolism Yeast
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