Monitoring Astrocytic Proteome Dynamics by Cell Type-Specific Protein Labeling

The ability of the nervous system to undergo long-term plasticity is based on changes in cellular and synaptic proteomes. While many studies have explored dynamic alterations in neuronal proteomes during plasticity, there has been less attention paid to the astrocytic counterpart. Indeed, progress i...

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Veröffentlicht in:	PloS one 2015-12, Vol.10 (12), p.e0145451
Hauptverfasser:	Müller, Anke, Stellmacher, Anne, Freitag, Christine E, Landgraf, Peter, Dieterich, Daniela C
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - analogs & derivatives Alanine - chemistry Amino acids Analysis Animals Astrocytes Astrocytes - cytology Astrocytes - drug effects Astrocytes - metabolism Attention Azides - analysis Azides - chemistry Brain Brain research Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - pharmacology Cell culture Coculture Techniques Communication Connexin 43 Dissociation Gene expression Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism HEK293 Cells Humans Insects Labeling Labelling Mass spectrometry Metabolism Methionine-tRNA Ligase - genetics Methionine-tRNA Ligase - metabolism Nervous system Neurobiology Neuroglia - cytology Neuronal-glial interactions Neurons Neurosciences Norleucine - analogs & derivatives Norleucine - analysis Norleucine - chemistry Pharmacology Plastic foam Plastic properties Plasticity Protein Biosynthesis Protein expression Protein synthesis Proteins Proteins - chemistry Proteins - metabolism Proteome Proteomes Proteomics Proteomics - methods Rats, Wistar Ribosomal protein L10a Rodents Scientific imaging Synaptic plasticity Synthesis Tagging Toxicology Transfer RNA tRNA
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