A Modified Murine Embryonic Stem Cell Test for Evaluating the Teratogenic Effects of Drugs on Early Embryogenesis

Mammalian fetal development is easily disrupted by exogenous agents, making it essential to test new drug candidates for embryotoxicity and teratogenicity. To standardize the testing of drugs that might be used to treat pregnant women, the U.S. Food and Drug Administration (FDA) formulated special g...

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Veröffentlicht in:	PloS one 2015-12, Vol.10 (12), p.e0145286
Hauptverfasser:	Yu, Ruoxing, Miyamura, Norio, Okamoto-Uchida, Yoshimi, Arima, Norie, Ishigami-Yuasa, Mari, Kagechika, Hiroyuki, Nishina, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Benzodiazepines - toxicity Bioengineering Biology Biomarkers - metabolism Biomedical materials Cardiomyocytes Cell Differentiation - drug effects Chemical compounds Drug development Drugs Embryogenesis Embryoid Bodies - drug effects Embryoid Bodies - physiology Embryonic development Embryonic Development - drug effects Embryonic growth stage Embryonic stem cells Embryos Fetal development Fetuses Gene expression Gene Expression - drug effects Kinases Medical research Medical screening Mice Molecular modelling Mouse Embryonic Stem Cells - drug effects Mouse Embryonic Stem Cells - physiology Neurogenesis Pharmaceutical sciences Pharmacovigilance Physiological aspects Pregnancy Prescription drugs Primitive streak Quality Regulatory agencies Stem cells Teratogenesis Teratogenicity Teratogens - classification Teratogens - toxicity Toxicity Tests Tretinoin - toxicity
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