Role of Epithelial-Mesenchyme Transition in Chlamydia Pathogenesis

Chlamydia trachomatis genital infection in women causes serious adverse reproductive complications, and is a strong co-factor for human papilloma virus (HPV)-associated cervical epithelial carcinoma. We tested the hypothesis that Chlamydia induces epithelial-mesenchyme transition (EMT) involving T c...

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Veröffentlicht in:	PloS one 2015-12, Vol.10 (12), p.e0145198-e0145198
Hauptverfasser:	Igietseme, Joseph U, Omosun, Yusuf, Stuchlik, Olga, Reed, Matthew S, Partin, James, He, Qing, Joseph, Kahaliah, Ellerson, Debra, Bollweg, Brigid, George, Zenas, Eko, Francis O, Bandea, Claudiu, Liu, Hsi, Yang, Genyan, Shieh, Wun-Ju, Pohl, Jan, Karem, Kevin, Black, Carolyn M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteria Cadherins - genetics Cadherins - metabolism Caspase inhibitors Caspases - metabolism Cell activation Cervix Chlamydia Chlamydia Infections - metabolism Chlamydia Infections - pathology Chlamydia trachomatis Complications Complications and side effects Connexin 43 Deactivation Development and progression Disease control Ductile-brittle transition E-cadherin Epithelial cells Epithelial-Mesenchymal Transition Epithelium Female Fertility Fibronectin Fibronectins - genetics Fibronectins - metabolism Fibrosis Fracture mechanics Gelatinase B HeLa Cells Homeobox Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Human papillomavirus Humans Immunohistochemistry Inactivation Infertility Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Lymphocytes T Markers Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Mesenchyme Mice Mice, Inbred C57BL MicroRNAs - genetics miRNA Papillomavirus infections Pathogenesis Patient outcomes Protein binding Proteins Proteomics Regulators Ribonucleic acid Risk factors RNA Rodents Sexually transmitted diseases Signaling Snail Family Transcription Factors STD T-cadherin Thrombospondin 1 - genetics Thrombospondin 1 - metabolism Transcription Factors - genetics Transcription Factors - metabolism Tumor necrosis factor Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α Tumorigenesis Viruses Zinc Zinc Finger E-box-Binding Homeobox 1 Zinc finger proteins
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