NDK Interacts with FtsZ and Converts GDP to GTP to Trigger FtsZ Polymerisation--A Novel Role for NDK

Nucleoside diphosphate kinase (NDK), conserved across bacteria to humans, synthesises NTP from NDP and ATP. The eukaryotic homologue, the NDPK, uses ATP to phosphorylate the tubulin-bound GDP to GTP for tubulin polymerisation. The bacterial cytokinetic protein FtsZ, which is the tubulin homologue, a...

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Veröffentlicht in:	PloS one 2015-12, Vol.10 (12), p.e0143677-e0143677
Hauptverfasser:	Mishra, Saurabh, Jakkala, Kishor, Srinivasan, Ramanujam, Arumugam, Muthu, Ranjeri, Raghavendra, Gupta, Prabuddha, Rajeswari, Haryadi, Ajitkumar, Parthasarathi
Format:	Artikel
Sprache:	eng
Schlagworte:	Addition polymerization Adenosine Triphosphate - metabolism ATP Bacillus subtilis Bacteria Bacterial proteins Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Biology Cell cycle Cell division Chemical synthesis Chromatography Crosslinking Cytokines Cytoskeletal Proteins - chemistry Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism E coli Escherichia coli Gel electrophoresis Guanosine Diphosphate - metabolism Guanosine triphosphate Guanosine Triphosphate - biosynthesis Homology Immunoprecipitation Light scattering Low level Microscopy, Electron, Transmission Morphology Mutation Mycobacterium smegmatis Mycobacterium smegmatis - genetics Mycobacterium smegmatis - metabolism Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - metabolism Nucleoside-diphosphate kinase Nucleoside-Diphosphate Kinase - genetics Nucleoside-Diphosphate Kinase - metabolism Pelleting Phosphorylation Polymerization Polymers Protein Structure, Quaternary Proteins Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Science Sodium lauryl sulfate Species Substrates Thin layer chromatography Tuberculosis Tubulin
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