A Flexible, Efficient Binomial Mixed Model for Identifying Differential DNA Methylation in Bisulfite Sequencing Data

Identifying sources of variation in DNA methylation levels is important for understanding gene regulation. Recently, bisulfite sequencing has become a popular tool for investigating DNA methylation levels. However, modeling bisulfite sequencing data is complicated by dramatic variation in coverage a...

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Veröffentlicht in:	PLoS genetics 2015-11, Vol.11 (11), p.e1005650-e1005650
Hauptverfasser:	Lea, Amanda J, Tung, Jenny, Zhou, Xiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Algorithms Alzheimers disease Analysis Arabidopsis thaliana CpG Islands - genetics Datasets Deoxyribonucleic acid DNA DNA methylation DNA Methylation - genetics Epigenetics Experiments Gene expression Genetic aspects Genomes Grants High-Throughput Nucleotide Sequencing Humans Methods Methylation Parameter estimation Physiological aspects Population Sequence Analysis, DNA Software Studies
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