Dengue Virus Non-structural Protein 1 Modulates Infectious Particle Production via Interaction with the Structural Proteins

Non-structural protein 1 (NS1) is one of the most enigmatic proteins of the Dengue virus (DENV), playing distinct functions in immune evasion, pathogenesis and viral replication. The recently reported crystal structure of DENV NS1 revealed its peculiar three-dimensional fold; however, detailed infor...

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Veröffentlicht in:	PLoS pathogens 2015-11, Vol.11 (11), p.e1005277
Hauptverfasser:	Scaturro, Pietro, Cortese, Mirko, Chatel-Chaix, Laurent, Fischl, Wolfgang, Bartenschlager, Ralf
Format:	Artikel
Sprache:	eng
Schlagworte:	Atoms & subatomic particles Care and treatment Cell Line Complications and side effects Crystals Dengue Dengue fever Dengue Virus - physiology Endoplasmic reticulum Experiments Humans Immunoglobulins Immunoprecipitation - methods Infections Localization Microscopy Molecular weight Mutagenesis, Site-Directed - methods Pathogenesis Proteins RNA, Viral - genetics Structure Viral Nonstructural Proteins - metabolism Virion - physiology Virus Replication
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