Diversity, Antimicrobial Action and Structure-Activity Relationship of Buffalo Cathelicidins

Cathelicidins are an ancient class of antimicrobial peptides (AMPs) with broad spectrum bactericidal activities. In this study, we investigated the diversity and biological activity of cathelicidins of buffalo, a species known for its disease resistance. A series of new homologs of cathelicidin4 (CA...

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Veröffentlicht in:	PloS one 2015-12, Vol.10 (12), p.e0144741-e0144741
Hauptverfasser:	Brahma, Biswajit, Patra, Mahesh Chandra, Karri, Satyanagalakshmi, Chopra, Meenu, Mishra, Purusottam, De, Bidhan Chandra, Kumar, Sushil, Mahanty, Sourav, Thakur, Kiran, Poluri, Krishna Mohan, Datta, Tirtha Kumar, De, Sachinandan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Antibiotics Antiinfectives and antibacterials Antimicrobial activity Antimicrobial Cationic Peptides - chemistry Antimicrobial Cationic Peptides - genetics Antimicrobial Cationic Peptides - pharmacology Antimicrobial peptides Bacteria Bacteria - drug effects Biodiversity Biological activity Biotechnology Budding Buffaloes Cathelicidins Cathelicidins - chemistry Cathelicidins - classification Cathelicidins - genetics Cathelicidins - pharmacology Cell Membrane - drug effects Cell Membrane - metabolism Cell Membrane - ultrastructure Cell Membrane Permeability - drug effects Cloning Cysteine proteinases Cytokines - genetics Cytokines - metabolism Cytotoxicity Deoxyribonucleic acid Disease resistance DNA Dosage and administration Drug resistance Eukaryotes Fibroblasts - drug effects Fibroblasts - metabolism Gene Dosage Gene Expression Regulation - drug effects Genes Genomics Geometry Homology Immunity Inflammation Inflammation Mediators Inflammatory response Innate immunity Mammals Microbial Sensitivity Tests Mimicry Models, Molecular Molecular Sequence Data Peptides Peptidomimetics Phylogeny Plasmids Protein Binding Protein Conformation Protein structure Secondary structure Sequence Alignment Species diversity Structure-Activity Relationship Toxicity Trends
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