Rosiglitazone Suppresses In Vitro Seizures in Hippocampal Slice by Inhibiting Presynaptic Glutamate Release in a Model of Temporal Lobe Epilepsy

Peroxisomal proliferator-activated receptor gamma (PPARγ) is a nuclear hormone receptor whose agonist, rosiglitazone has a neuroprotective effect to hippocampal neurons in pilocarpine-induced seizures. Hippocampal slice preparations treated in Mg2+ free medium can induce ictal and interictal-like ep...

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Veröffentlicht in:	PloS one 2015-12, Vol.10 (12), p.e0144806-e0144806
Hauptverfasser:	Wong, Shi-Bing, Cheng, Sin-Jhong, Hung, Wei-Chen, Lee, Wang-Tso, Min, Ming-Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Alzheimer's disease Anilides - pharmacology Animals Brain Brain slice preparation Buddhism CA1 Region, Hippocampal - drug effects CA1 Region, Hippocampal - metabolism CA1 Region, Hippocampal - pathology Culture Media - chemistry Culture Media - pharmacology Cytokines Discharge Discharge frequency Dosage and administration Drug therapy Drugs Epilepsy Epilepsy, Temporal Lobe - drug therapy Epilepsy, Temporal Lobe - genetics Epilepsy, Temporal Lobe - metabolism Epilepsy, Temporal Lobe - pathology Excitatory Postsynaptic Potentials - drug effects Excitotoxicity Firing pattern Gene expression Gene Expression Regulation Glucose Glutamate Glutamic Acid - metabolism Glutamic acid receptors (ionotropic) Health aspects Hippocampus Ischemia Kinases Life sciences Magnesium Magnesium - pharmacology Microtomy Models, Biological N-Methyl-D-aspartic acid receptors Neurons Neurons - drug effects Neurons - metabolism Neurons - pathology Neuroprotection Neuroprotective Agents - antagonists & inhibitors Neuroprotective Agents - pharmacology Neurotransmitter release Parkinson's disease Patient outcomes Pediatrics Pilocarpine PPAR gamma - antagonists & inhibitors PPAR gamma - genetics PPAR gamma - metabolism Prevention Rats Rats, Sprague-Dawley Receptors Receptors, N-Methyl-D-Aspartate - agonists Receptors, N-Methyl-D-Aspartate - genetics Receptors, N-Methyl-D-Aspartate - metabolism Rodents Rosiglitazone Rosiglitazone maleate Seizures Seizures (Medicine) Seizures - drug therapy Seizures - genetics Seizures - metabolism Seizures - pathology Synapses Synaptic transmission Synaptic Transmission - drug effects Temporal lobe Thiazolidinediones - antagonists & inhibitors Thiazolidinediones - pharmacology Tissue Culture Techniques Zoology
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