Striatal Dopamine D2/D3 Receptor Availability Is Associated with Executive Function in Healthy Controls but Not Methamphetamine Users

Dopamine D2/D3 receptor availability in the striatum has been linked with executive function in healthy individuals, and is below control levels among drug addicts, possibly contributing to diminished executive function in the latter group. This study tested for an association of striatal D2/D3 rece...

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Veröffentlicht in:	PloS one 2015-12, Vol.10 (12), p.e0143510
Hauptverfasser:	Ballard, Michael E, Dean, Andy C, Mandelkern, Mark A, London, Edythe D
Format:	Artikel
Sprache:	eng
Schlagworte:	Addicts Adult Amphetamine-Related Disorders - metabolism Availability Brain research Case-Control Studies Cognitive ability Corpus Striatum - metabolism Dopamine Dopamine D2 receptors Dopamine D3 receptors Drug abuse Education Emission analysis Executive function Executive Function - drug effects Executive Function - physiology Female Health care policy Humans Laboratories Male Methamphetamine Methamphetamine - adverse effects Middle Aged Neostriatum Neuropsychological Tests Neurosciences Positron emission Positron emission tomography Positron-Emission Tomography - methods Psychiatry Receptors Receptors, Dopamine D2 - metabolism Receptors, Dopamine D3 - metabolism Signaling Studies Substance-Related Disorders - metabolism
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