Luteolin Inhibits Ischemia/Reperfusion-Induced Myocardial Injury in Rats via Downregulation of microRNA-208b-3p

Luteolin (LUT), a kind of flavonoid which is extracted from a variety of diets, has been reported to convey protective effects of various diseases. Recent researches have suggested that LUT can carry out cardioprotective effects during ischemia/reperfusion (I/R). However, there have no reports on wh...

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Veröffentlicht in:	PloS one 2015-12, Vol.10 (12), p.e0144877-e0144877
Hauptverfasser:	Bian, Chen, Xu, Tongda, Zhu, Hong, Pan, Defeng, Liu, Yang, Luo, Yuanyuan, Wu, Pei, Li, Dongye
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Animals Annexin V Anoxia Apoptosis Bax protein Bcl-2 protein Cardiology Cardiotonic Agents - pharmacology Cardiovascular disease Caspase Caspase 3 - genetics Caspase 3 - metabolism Caspase-3 Causes of Cell Line Complications and side effects Coronary vessels Cytometry Ets-1 protein Flavonoids Flow cytometry Fluorescein Fluorescein isothiocyanate Gene expression Gene Expression Regulation Genes Genes, Reporter Genetic regulation Health aspects Heart Heart attacks Homology Hospitals Inflammation Injuries Iodides Ischemia Isothiocyanate Luciferases - genetics Luciferases - metabolism Luteolin - pharmacology Male MicroRNA MicroRNAs MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism Miranda miRNA mRNA Myocardial diseases Myocardial Reperfusion Injury - genetics Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - prevention & control Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Oligonucleotides - genetics Oligonucleotides - metabolism Organ Culture Techniques Polymerase chain reaction Pretreatment Prevention Propidium iodide Proto-Oncogene Protein c-ets-1 - antagonists & inhibitors Proto-Oncogene Protein c-ets-1 - genetics Proto-Oncogene Protein c-ets-1 - metabolism Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Rats Rats, Sprague-Dawley Reperfusion Reperfusion injury Ribonucleic acid RNA Rodents Signal Transduction siRNA Viruses
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