Amiodarone Induces Overexpression of Similar to Versican b to Repress the EGFR/Gsk3b/Snail Signaling Axis during Cardiac Valve Formation of Zebrafish Embryos

Although Amiodarone, a class III antiarrhythmic drug, inhibits zebrafish cardiac valve formation, the detailed molecular pathway is still unclear. Here, we proved that Amiodarone acts as an upstream regulator, stimulating similar to versican b (s-vcanb) overexpression at zebrafish embryonic heart an...

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Veröffentlicht in:	PloS one 2015-12, Vol.10 (12), p.e0144751-e0144751
Hauptverfasser:	Lee, Hung-Chieh, Lo, Hao-Chan, Lo, Dao-Ming, Su, Mai-Yan, Hu, Jia-Rung, Wu, Chin-Chieh, Chang, Sheng-Nan, Dai, Ming-Shen, Tsai, Chia-Ti, Tsai, Huai-Jen
Format:	Artikel
Sprache:	eng
Schlagworte:	Amiodarone Amiodarone - pharmacology Animals Blotting, Western Breast cancer Cell growth Cellular biology Cellular signal transduction Complications and side effects Danio rerio Dosage and administration Embryo, Nonmammalian - cytology Embryo, Nonmammalian - drug effects Embryo, Nonmammalian - metabolism Embryonic development Embryos Epidermal growth factor Epidermal growth factor receptors Extracellular matrix Gene Expression Regulation, Developmental - drug effects Genes Genes, erbB-1 - genetics Genetic aspects Glycogen Synthase Kinase 3 beta - genetics Glycogen Synthase Kinase 3 beta - metabolism Heart Heart diseases Heart valves Heart Valves - cytology Heart Valves - drug effects Hematology Hospitals In Situ Hybridization Inhibition Organogenesis - drug effects Phosphorylation Physiological aspects Signal Transduction - drug effects Signaling Snail Family Transcription Factors - genetics Snail Family Transcription Factors - metabolism Up-Regulation Vasodilator Agents - pharmacology Versican Versicans - pharmacology Zebrafish Zebrafish - genetics Zebrafish - growth & development Zebrafish - metabolism Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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