Rare Variants in Transcript and Potential Regulatory Regions Explain a Small Percentage of the Missing Heritability of Complex Traits in Cattle

The proportion of genetic variation in complex traits explained by rare variants is a key question for genomic prediction, and for identifying the basis of "missing heritability"--the proportion of additive genetic variation not captured by common variants on SNP arrays. Sequence variants...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2015-12, Vol.10 (12), p.e0143945-e0143945
Hauptverfasser:	Gonzalez-Recio, Oscar, Daetwyler, Hans D, MacLeod, Iona M, Pryce, Jennie E, Bowman, Phil J, Hayes, Ben J, Goddard, Michael E
Format:	Artikel
Sprache:	eng
Schlagworte:	Accuracy Analysis Animals Arrays Bioinformatics Biology Bovidae Cattle Cattle - genetics Density Economic development Fertility Fitness Futures Genetic diversity Genetic variance Genomes Genotypes Health aspects Heritability Milk Mutation Pedigree Polymorphism, Single Nucleotide Progeny Regulatory sequences Regulatory Sequences, Nucleic Acid Reproductive fitness RNA, Messenger - genetics Single nucleotide polymorphisms Single-nucleotide polymorphism Transcription Transcription (Genetics) Variation Yield
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The proportion of genetic variation in complex traits explained by rare variants is a key question for genomic prediction, and for identifying the basis of "missing heritability"--the proportion of additive genetic variation not captured by common variants on SNP arrays. Sequence variants in transcript and regulatory regions from 429 sequenced animals were used to impute high density SNP genotypes of 3311 Holstein sires to sequence. There were 675,062 common variants (MAF>0.05), 102,549 uncommon variants (0.01
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0143945