Clinicopathologica Epidemiological Characteristics and Change Tendencies of Renal Cell Carcinoma in Shanxi Province of China from 2005 to 2014
RCC is the most common solid renal malignancy in adults worldwide. To provide the insight of clinicopathologica epidemiological characteristics and change tendencies of renal cell carcinoma (RCC), 2154 cases were collected from Shanxi Province of China, including diagnose time, age, gender, tumor si...
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| description | RCC is the most common solid renal malignancy in adults worldwide. To provide the insight of clinicopathologica epidemiological characteristics and change tendencies of renal cell carcinoma (RCC), 2154 cases were collected from Shanxi Province of China, including diagnose time, age, gender, tumor size, Fuhrman grade, tumor stage, tumor location, local advance or distant metastasis and first symptom from 2005 to 2014. This retrospectively investigation, as its general objective, was to analyze the clinicopathologica epidemiological characteristics and the change tendencies of RCC.
Between 2005 and 2014, 2154 patients who were diagnosed with RCC in three large tertiary hospitals at Shanxi Province were included. The patients' demographic features, pathological diagnoses and metastatic statuses were analyzed. Statistics methods include the chi-squared test, analysis of variance, Spearman's correlation analysis, Logistic regression and ARIMA modeling.
Of the 2154 included patients, the constituent ratio of female /male was 63.1% and 36.9%, with the median age of 57 years old. Fuhrman grade distributions differed significantly between males and females (p = 0.024). Also, a significant difference in tumor size was found by different clinical stages (p < 0.001), with a linear correlation (p < 0.001). Moreover, Spearman's analysis indicated tumor grade has a negative correlation with female (p = 0.009) and a positive correlation with tumor size (p = 0.000). It was found that the tumor diameter is bigger in the left side (p = 0.022). Furthermore, the metastasis rate was higher in the bigger tumor (p < 0.001) and the left-sided tumors (p = 0.027). Logistic regression also showed that tumor size is a risk factor for metastasis (OR = 1.724). The risk of local advance or distant metastasis in the left kidney was 1.6-fold greater than that of the right kidney. From 2005 to 2014 the number of RCC cases gradually increased (mainly for pathological grade II and III, but grade I and IV), while the average tumor size decreased, showing the severity increase mildly. Base on the results of a time series analysis-prediction the average RCC size would continue to decrease from the first quarter of 2015 to the fourth quarter of 2016.
The cases of RCC increased from 2005 to 2014 with clear cell type as the main pathological type in this population. The characteristics in the constituent ratios of the RCC vary depending on gender, pathological grade, tumor size, and location, which |
| doi_str_mv | 10.1371/journal.pone.0144246 |
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Between 2005 and 2014, 2154 patients who were diagnosed with RCC in three large tertiary hospitals at Shanxi Province were included. The patients' demographic features, pathological diagnoses and metastatic statuses were analyzed. Statistics methods include the chi-squared test, analysis of variance, Spearman's correlation analysis, Logistic regression and ARIMA modeling.
Of the 2154 included patients, the constituent ratio of female /male was 63.1% and 36.9%, with the median age of 57 years old. Fuhrman grade distributions differed significantly between males and females (p = 0.024). Also, a significant difference in tumor size was found by different clinical stages (p < 0.001), with a linear correlation (p < 0.001). Moreover, Spearman's analysis indicated tumor grade has a negative correlation with female (p = 0.009) and a positive correlation with tumor size (p = 0.000). It was found that the tumor diameter is bigger in the left side (p = 0.022). Furthermore, the metastasis rate was higher in the bigger tumor (p < 0.001) and the left-sided tumors (p = 0.027). Logistic regression also showed that tumor size is a risk factor for metastasis (OR = 1.724). The risk of local advance or distant metastasis in the left kidney was 1.6-fold greater than that of the right kidney. From 2005 to 2014 the number of RCC cases gradually increased (mainly for pathological grade II and III, but grade I and IV), while the average tumor size decreased, showing the severity increase mildly. Base on the results of a time series analysis-prediction the average RCC size would continue to decrease from the first quarter of 2015 to the fourth quarter of 2016.
The cases of RCC increased from 2005 to 2014 with clear cell type as the main pathological type in this population. The characteristics in the constituent ratios of the RCC vary depending on gender, pathological grade, tumor size, and location, which may be the important factors impacting treatment and prognosis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0144246</identifier><identifier>PMID: 26633179</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Adults ; Aged ; Aged, 80 and over ; Analysis ; Autoregressive models ; Cancer therapies ; Carcinoma, Renal Cell - epidemiology ; Carcinoma, Renal Cell - pathology ; China - epidemiology ; Clear cell-type renal cell carcinoma ; Correlation ; Correlation analysis ; Data collection ; Demographics ; Development and progression ; Epidemiology ; Female ; Females ; Genetic aspects ; Health aspects ; Hospitals ; Humans ; Incidence ; Kidney cancer ; Kidney Neoplasms - epidemiology ; Kidney Neoplasms - pathology ; Kidneys ; Male ; Males ; Malignancy ; Medical diagnosis ; Medical prognosis ; Metastases ; Metastasis ; Middle Aged ; Mortality ; Neoplasm Grading ; Neoplasm Metastasis - pathology ; Neoplasm Staging ; Pathological histology ; Pathology ; Patients ; Prognosis ; Regression analysis ; Renal cell carcinoma ; Retrospective Studies ; Risk factors ; Statistical analysis ; Statistical methods ; Statistical tests ; Studies ; Time series ; Trends ; Tumors ; Urology ; Variance analysis ; Young Adult</subject><ispartof>PloS one, 2015-12, Vol.10 (12), p.e0144246</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Bai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Bai et al 2015 Bai et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-fe600310acdc7e96de08ec1fc783ecd76397385140f7e3ae5f77a9d73f9b354e3</citedby><cites>FETCH-LOGICAL-c692t-fe600310acdc7e96de08ec1fc783ecd76397385140f7e3ae5f77a9d73f9b354e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669184/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669184/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,2098,2917,23849,27907,27908,53774,53776,79351,79352</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26633179$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>He, Weijing</contributor><creatorcontrib>Bai, Tao</creatorcontrib><creatorcontrib>Wang, Li</creatorcontrib><creatorcontrib>Wang, Dongwen</creatorcontrib><creatorcontrib>Yuan, Xiaobin</creatorcontrib><creatorcontrib>Bai, Wei</creatorcontrib><creatorcontrib>Yang, Qin</creatorcontrib><creatorcontrib>Yang, Xian</creatorcontrib><title>Clinicopathologica Epidemiological Characteristics and Change Tendencies of Renal Cell Carcinoma in Shanxi Province of China from 2005 to 2014</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>RCC is the most common solid renal malignancy in adults worldwide. To provide the insight of clinicopathologica epidemiological characteristics and change tendencies of renal cell carcinoma (RCC), 2154 cases were collected from Shanxi Province of China, including diagnose time, age, gender, tumor size, Fuhrman grade, tumor stage, tumor location, local advance or distant metastasis and first symptom from 2005 to 2014. This retrospectively investigation, as its general objective, was to analyze the clinicopathologica epidemiological characteristics and the change tendencies of RCC.
Between 2005 and 2014, 2154 patients who were diagnosed with RCC in three large tertiary hospitals at Shanxi Province were included. The patients' demographic features, pathological diagnoses and metastatic statuses were analyzed. Statistics methods include the chi-squared test, analysis of variance, Spearman's correlation analysis, Logistic regression and ARIMA modeling.
Of the 2154 included patients, the constituent ratio of female /male was 63.1% and 36.9%, with the median age of 57 years old. Fuhrman grade distributions differed significantly between males and females (p = 0.024). Also, a significant difference in tumor size was found by different clinical stages (p < 0.001), with a linear correlation (p < 0.001). Moreover, Spearman's analysis indicated tumor grade has a negative correlation with female (p = 0.009) and a positive correlation with tumor size (p = 0.000). It was found that the tumor diameter is bigger in the left side (p = 0.022). Furthermore, the metastasis rate was higher in the bigger tumor (p < 0.001) and the left-sided tumors (p = 0.027). Logistic regression also showed that tumor size is a risk factor for metastasis (OR = 1.724). The risk of local advance or distant metastasis in the left kidney was 1.6-fold greater than that of the right kidney. From 2005 to 2014 the number of RCC cases gradually increased (mainly for pathological grade II and III, but grade I and IV), while the average tumor size decreased, showing the severity increase mildly. Base on the results of a time series analysis-prediction the average RCC size would continue to decrease from the first quarter of 2015 to the fourth quarter of 2016.
The cases of RCC increased from 2005 to 2014 with clear cell type as the main pathological type in this population. The characteristics in the constituent ratios of the RCC vary depending on gender, pathological grade, tumor size, and location, which may be the important factors impacting treatment and prognosis.</description><subject>Adult</subject><subject>Adults</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Autoregressive models</subject><subject>Cancer therapies</subject><subject>Carcinoma, Renal Cell - epidemiology</subject><subject>Carcinoma, Renal Cell - pathology</subject><subject>China - epidemiology</subject><subject>Clear cell-type renal cell carcinoma</subject><subject>Correlation</subject><subject>Correlation analysis</subject><subject>Data collection</subject><subject>Demographics</subject><subject>Development and progression</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Females</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Incidence</subject><subject>Kidney cancer</subject><subject>Kidney Neoplasms - epidemiology</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidneys</subject><subject>Male</subject><subject>Males</subject><subject>Malignancy</subject><subject>Medical diagnosis</subject><subject>Medical prognosis</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Metastasis - pathology</subject><subject>Neoplasm Staging</subject><subject>Pathological histology</subject><subject>Pathology</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Regression analysis</subject><subject>Renal cell carcinoma</subject><subject>Retrospective Studies</subject><subject>Risk factors</subject><subject>Statistical analysis</subject><subject>Statistical methods</subject><subject>Statistical tests</subject><subject>Studies</subject><subject>Time series</subject><subject>Trends</subject><subject>Tumors</subject><subject>Urology</subject><subject>Variance analysis</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1Fr1TAUx4sobk6_gWhAEH2416RJk_ZFGJepFwaTbfoa0vS0zaU3uUvaMb-En9nU241b2YMUkvb0d_4n-ScnSV4TvCRUkE8bN3iruuXOWVhiwljK-JPkmBQ0XfAU06cH70fJixA2GGc05_x5cpRyTikRxXHye9UZa7Tbqb51nWuMVuhsZyrYmumzQ6tWeaV78Cb0RgekbDXGbAPoGmwFVhsIyNXoEuyIQxcH5bWxbquQsegqwncGfffu1lgNI7pqjVWo9m6L0rgu1Ls4E_YyeVarLsCraT5Jfnw5u159W5xffF2vTs8Xmhdpv6iBY0wJVrrSAgpeAc5Bk1qLnIKuBKeFoHlGGK4FUAVZLYQqKkHroqQZA3qSvN3r7joX5GRlkETQAguRZjQS6z1RObWRO2-2yv-SThn5N-B8I5WPdnQgVckZj_q8pJjptMzTLNesrDjnJc5SFbU-T9WGcguVBtt71c1E53-saWXjbiXjvCA5iwIfJgHvbgYIvdyaoKPPyoIbxnWziJLoZETf_YM-vruJalTcgLG1i3X1KCpPGeUZLzAfyy4foeIzXg8d711tYnyW8HGWEJke7vpGDSHI9dXl_7MXP-fs-wO2BdX1bXDd0Btnwxxke1B7F4KH-sFkguXYNvduyLFt5NQ2Me3N4QE9JN33Cf0D82cR9Q</recordid><startdate>20151203</startdate><enddate>20151203</enddate><creator>Bai, Tao</creator><creator>Wang, Li</creator><creator>Wang, Dongwen</creator><creator>Yuan, Xiaobin</creator><creator>Bai, Wei</creator><creator>Yang, Qin</creator><creator>Yang, Xian</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20151203</creationdate><title>Clinicopathologica Epidemiological Characteristics and Change Tendencies of Renal Cell Carcinoma in Shanxi Province of China from 2005 to 2014</title><author>Bai, Tao ; Wang, Li ; Wang, Dongwen ; Yuan, Xiaobin ; Bai, Wei ; Yang, Qin ; Yang, Xian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-fe600310acdc7e96de08ec1fc783ecd76397385140f7e3ae5f77a9d73f9b354e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Autoregressive models</topic><topic>Cancer therapies</topic><topic>Carcinoma, Renal Cell - epidemiology</topic><topic>Carcinoma, Renal Cell - pathology</topic><topic>China - epidemiology</topic><topic>Clear cell-type renal cell carcinoma</topic><topic>Correlation</topic><topic>Correlation analysis</topic><topic>Data collection</topic><topic>Demographics</topic><topic>Development and progression</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Females</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Incidence</topic><topic>Kidney cancer</topic><topic>Kidney Neoplasms - epidemiology</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidneys</topic><topic>Male</topic><topic>Males</topic><topic>Malignancy</topic><topic>Medical diagnosis</topic><topic>Medical prognosis</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Metastasis - pathology</topic><topic>Neoplasm Staging</topic><topic>Pathological histology</topic><topic>Pathology</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Regression analysis</topic><topic>Renal cell carcinoma</topic><topic>Retrospective Studies</topic><topic>Risk factors</topic><topic>Statistical analysis</topic><topic>Statistical methods</topic><topic>Statistical tests</topic><topic>Studies</topic><topic>Time series</topic><topic>Trends</topic><topic>Tumors</topic><topic>Urology</topic><topic>Variance analysis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bai, Tao</creatorcontrib><creatorcontrib>Wang, Li</creatorcontrib><creatorcontrib>Wang, Dongwen</creatorcontrib><creatorcontrib>Yuan, Xiaobin</creatorcontrib><creatorcontrib>Bai, Wei</creatorcontrib><creatorcontrib>Yang, Qin</creatorcontrib><creatorcontrib>Yang, Xian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bai, Tao</au><au>Wang, Li</au><au>Wang, Dongwen</au><au>Yuan, Xiaobin</au><au>Bai, Wei</au><au>Yang, Qin</au><au>Yang, Xian</au><au>He, Weijing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinicopathologica Epidemiological Characteristics and Change Tendencies of Renal Cell Carcinoma in Shanxi Province of China from 2005 to 2014</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-12-03</date><risdate>2015</risdate><volume>10</volume><issue>12</issue><spage>e0144246</spage><pages>e0144246-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>RCC is the most common solid renal malignancy in adults worldwide. To provide the insight of clinicopathologica epidemiological characteristics and change tendencies of renal cell carcinoma (RCC), 2154 cases were collected from Shanxi Province of China, including diagnose time, age, gender, tumor size, Fuhrman grade, tumor stage, tumor location, local advance or distant metastasis and first symptom from 2005 to 2014. This retrospectively investigation, as its general objective, was to analyze the clinicopathologica epidemiological characteristics and the change tendencies of RCC.
Between 2005 and 2014, 2154 patients who were diagnosed with RCC in three large tertiary hospitals at Shanxi Province were included. The patients' demographic features, pathological diagnoses and metastatic statuses were analyzed. Statistics methods include the chi-squared test, analysis of variance, Spearman's correlation analysis, Logistic regression and ARIMA modeling.
Of the 2154 included patients, the constituent ratio of female /male was 63.1% and 36.9%, with the median age of 57 years old. Fuhrman grade distributions differed significantly between males and females (p = 0.024). Also, a significant difference in tumor size was found by different clinical stages (p < 0.001), with a linear correlation (p < 0.001). Moreover, Spearman's analysis indicated tumor grade has a negative correlation with female (p = 0.009) and a positive correlation with tumor size (p = 0.000). It was found that the tumor diameter is bigger in the left side (p = 0.022). Furthermore, the metastasis rate was higher in the bigger tumor (p < 0.001) and the left-sided tumors (p = 0.027). Logistic regression also showed that tumor size is a risk factor for metastasis (OR = 1.724). The risk of local advance or distant metastasis in the left kidney was 1.6-fold greater than that of the right kidney. From 2005 to 2014 the number of RCC cases gradually increased (mainly for pathological grade II and III, but grade I and IV), while the average tumor size decreased, showing the severity increase mildly. Base on the results of a time series analysis-prediction the average RCC size would continue to decrease from the first quarter of 2015 to the fourth quarter of 2016.
The cases of RCC increased from 2005 to 2014 with clear cell type as the main pathological type in this population. The characteristics in the constituent ratios of the RCC vary depending on gender, pathological grade, tumor size, and location, which may be the important factors impacting treatment and prognosis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26633179</pmid><doi>10.1371/journal.pone.0144246</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-12, Vol.10 (12), p.e0144246 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1739077253 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Adults Aged Aged, 80 and over Analysis Autoregressive models Cancer therapies Carcinoma, Renal Cell - epidemiology Carcinoma, Renal Cell - pathology China - epidemiology Clear cell-type renal cell carcinoma Correlation Correlation analysis Data collection Demographics Development and progression Epidemiology Female Females Genetic aspects Health aspects Hospitals Humans Incidence Kidney cancer Kidney Neoplasms - epidemiology Kidney Neoplasms - pathology Kidneys Male Males Malignancy Medical diagnosis Medical prognosis Metastases Metastasis Middle Aged Mortality Neoplasm Grading Neoplasm Metastasis - pathology Neoplasm Staging Pathological histology Pathology Patients Prognosis Regression analysis Renal cell carcinoma Retrospective Studies Risk factors Statistical analysis Statistical methods Statistical tests Studies Time series Trends Tumors Urology Variance analysis Young Adult |
| title | Clinicopathologica Epidemiological Characteristics and Change Tendencies of Renal Cell Carcinoma in Shanxi Province of China from 2005 to 2014 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T23%3A36%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinicopathologica%20Epidemiological%20Characteristics%20and%20Change%20Tendencies%20of%20Renal%20Cell%20Carcinoma%20in%20Shanxi%20Province%20of%20China%20from%202005%20to%202014&rft.jtitle=PloS%20one&rft.au=Bai,%20Tao&rft.date=2015-12-03&rft.volume=10&rft.issue=12&rft.spage=e0144246&rft.pages=e0144246-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0144246&rft_dat=%3Cgale_plos_%3EA436569064%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1739077253&rft_id=info:pmid/26633179&rft_galeid=A436569064&rft_doaj_id=oai_doaj_org_article_ab6467a96b304c2b8258c4bd666b052a&rfr_iscdi=true |