Physiologic Stresses Reveal a Salmonella Persister State and TA Family Toxins Modulate Tolerance to These Stresses

Bacterial persister cells are considered a basis for chronic infections and relapse caused by bacterial pathogens. Persisters are phenotypic variants characterized by low metabolic activity and slow or no replication. This low metabolic state increases pathogen tolerance to antibiotics and host immu...

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Veröffentlicht in:	PloS one 2015-12, Vol.10 (12), p.e0141343
Hauptverfasser:	Silva-Herzog, Eugenia, McDonald, Erin M, Crooks, Amy L, Detweiler, Corrella S
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antibiotics Bacteria Bacterial toxins Bacterial Toxins - genetics Bacterial Toxins - metabolism Cell survival Clonal deletion Developmental biology Disseminated infection Drug Tolerance - genetics E coli Escherichia coli Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Gene expression Gene Expression Regulation, Bacterial - drug effects Immunological tolerance Infections Loci Lymphatic system Macrophages Metabolism Pathogens Physiological aspects Population Proteins Salmonella Salmonella enterica Salmonella typhimurium - drug effects Salmonella typhimurium - genetics Salmonella typhimurium - metabolism Serotypes Stress (Physiology) Stresses Toxins Typhoid
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