Regulatory T Cell Responses to High-Dose Methylprednisolone in Active Systemic Lupus Erythematosus

A slight increase in the proportion of circulating regulatory T (Treg) cells has been reported in systemic lupus erythematosus (SLE) patients taking oral prednisone. The effects of intravenous (IV) high dose methylprednisolone (MP) on Tregs have not yet been described, especially in active SLE. We p...

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Veröffentlicht in:	PloS one 2015-12, Vol.10 (12), p.e0143689-e0143689
Hauptverfasser:	Mathian, Alexis, Jouenne, Romain, Chader, Driss, Cohen-Aubart, Fleur, Haroche, Julien, Fadlallah, Jehane, Claër, Laetitia, Musset, Lucile, Gorochov, Guy, Amoura, Zahir, Miyara, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Analysis Arthritis Autoimmune diseases CD4 antigen Chronic conditions Cytokines Dosage and administration Dose-Response Relationship, Drug Drug therapy Effector cells Female Follow-Up Studies Human health and pathology Humans Immune response Immunoregulation Immunosuppressive agents Infectious diseases Infusions, Intravenous Intravenous administration Leukocytes (mononuclear) Life Sciences Lupus Lupus Erythematosus, Systemic - drug therapy Lupus Erythematosus, Systemic - immunology Lymphocytes Lymphocytes T Male Methylprednisolone Methylprednisolone - administration & dosage Methylprednisolone - pharmacology Methylprednisolone - therapeutic use Middle Aged Patients Peripheral blood mononuclear cells Prednisone Systemic lupus erythematosus T cells T-Lymphocytes, Regulatory - drug effects Transcription factors Treatment Outcome Young Adult
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