Modelling of Thyroid Peroxidase Reveals Insights into Its Enzyme Function and Autoantigenicity

Thyroid peroxidase (TPO) catalyses the biosynthesis of thyroid hormones and is a major autoantigen in Hashimoto's disease--the most common organ-specific autoimmune disease. Epitope mapping studies have shown that the autoimmune response to TPO is directed mainly at two surface regions on the m...

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Veröffentlicht in:	PloS one 2015-12, Vol.10 (12), p.e0142615-e0142615
Hauptverfasser:	Le, Sarah N, Porebski, Benjamin T, McCoey, Julia, Fodor, James, Riley, Blake, Godlewska, Marlena, Góra, Monika, Czarnocka, Barbara, Banga, J Paul, Hoke, David E, Kass, Itamar, Buckle, Ashley M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antigenic determinants Antigens Autoantibodies Autoantigens - chemistry Autoantigens - immunology Autoantigens - metabolism Biochemistry Biosynthesis C-Terminus Care and treatment Cell Membrane - enzymology Coalescing Crystal structure Cytotoxicity Dimerization Dissociation Endocrinology Enzyme Stability Epidermal growth factor Epitope mapping Extracellular Space - enzymology Health education Hormones Humans Immunoglobulins Iodide peroxidase Iodide Peroxidase - chemistry Iodide Peroxidase - immunology Iodide Peroxidase - metabolism Iron-Binding Proteins - chemistry Iron-Binding Proteins - immunology Iron-Binding Proteins - metabolism Mapping Modelling Molecular biology Molecular Dynamics Simulation Molecular modelling Molecular Sequence Data Molecular structure Monomers Mutagenesis Peroxidase Protein Multimerization Protein Structure, Quaternary Protein Structure, Tertiary Proteins Risk factors Steric hindrance Thermodynamics Thyroid Thyroid diseases Thyroid hormones Thyroxine
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