Distinct Roles for CdtA and CdtC during Intoxication by Cytolethal Distending Toxins

Cytolethal distending toxins (CDTs) are heterotrimeric protein exotoxins produced by a diverse array of Gram-negative pathogens. The enzymatic subunit, CdtB, possesses DNase and phosphatidylinositol 3-4-5 trisphosphate phosphatase activities that induce host cell cycle arrest, cellular distension an...

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Veröffentlicht in:	PloS one 2015-11, Vol.10 (11), p.e0143977-e0143977
Hauptverfasser:	Dixon, Shandee D, Huynh, Melanie M, Tamilselvam, Batcha, Spiegelman, Lindsey M, Son, Sophia B, Eshraghi, Aria, Blanke, Steven R, Bradley, Kenneth A
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinobacillus actinomycetemcomitans Aggregatibacter actinomycetemcomitans Animals Apoptosis Bacterial Toxins - metabolism Biochemistry Biology Campylobacter Carbohydrates Care and treatment Cell Cycle Cell surface Cell Survival CHO Cells Cholesterol Cricetulus Cytotoxicity Deoxyribonuclease Deoxyribonucleic acid Diagnosis Distension DNA DNA damage E coli Endosomes Enteropathogenic Escherichia coli - metabolism Enteropathogenic Escherichia coli - physiology Epithelial cells Epithelial Cells - cytology Exotoxins Genetics Haemophilus ducreyi Haemophilus ducreyi - metabolism Haemophilus ducreyi - physiology HeLa Cells Hemophilus infections Host-Pathogen Interactions Humans Immunology Infections Intoxication Jurkat Cells Kinetics Lipids Localization Lymphocytes T Nuclei Pathogens Phosphatase Phosphatidylinositol Protein Transport Receptors Risk factors Sensitivity T cells T-Lymphocytes - cytology Toxins Typhoid
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