Inducible Knock-Down of the Mineralocorticoid Receptor in Mice Disturbs Regulation of the Renin-Angiotensin-Aldosterone System and Attenuates Heart Failure Induced by Pressure Overload

Mineralocorticoid receptor (MR) inactivation in mice results in early postnatal lethality. Therefore we generated mice in which MR expression can be silenced during adulthood by administration of doxycycline (Dox). Using a lentiviral approach, we obtained two lines of transgenic mice harboring a con...

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Veröffentlicht in:	PloS one 2015-11, Vol.10 (11), p.e0143954-e0143954
Hauptverfasser:	Montes-Cobos, Elena, Li, Xiao, Fischer, Henrike J, Sasse, André, Kügler, Sebastian, Didié, Michael, Toischer, Karl, Fassnacht, Martin, Dressel, Ralf, Reichardt, Holger M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldosterone Aldosterone - blood Angiotensin Animal tissues Animals Aorta Cardiology Cardiomyocytes Care and treatment Cloning Collagen Collagen - metabolism Deactivation Disease Models, Animal Doxycycline Echocardiography Electrolytes - urine Excretion Fibrosis Gene Expression Gene Silencing Genes Heart Heart diseases Heart failure Heart Failure - diagnosis Heart Failure - etiology Hypertension - complications Hypertension - genetics Hypertension - physiopathology Hypertrophy Immunology Inactivation Kidneys Lethality Ligands Mice Mice, Knockout Mineralocorticoids Physiology Receptors, Mineralocorticoid - deficiency Receptors, Mineralocorticoid - genetics Renin Renin - blood Renin-angiotensin system Renin-Angiotensin System - genetics Risk factors RNA, Small Interfering - genetics RNA-mediated interference Rodents Smooth muscle Sodium Stem cells Tightness Transgenic animals Transgenic mice
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