Circulating microRNAs and Outcome in Patients with Acute Heart Failure
The biomarker value of circulating microRNAs (miRNAs) has been extensively addressed in patients with acute coronary syndrome. However, prognostic performances of miRNAs in patients with acute heart failure (AHF) has received less attention. A test cohort of 294 patients with acute dyspnea (236 AHF...
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| creator | Seronde, Marie-France Vausort, Mélanie Gayat, Etienne Goretti, Emeline Ng, Leong L Squire, Iain B Vodovar, Nicolas Sadoune, Malha Samuel, Jane-Lise Thum, Thomas Solal, Alain Cohen Laribi, Said Plaisance, Patrick Wagner, Daniel R Mebazaa, Alexandre Devaux, Yvan |
| description | The biomarker value of circulating microRNAs (miRNAs) has been extensively addressed in patients with acute coronary syndrome. However, prognostic performances of miRNAs in patients with acute heart failure (AHF) has received less attention.
A test cohort of 294 patients with acute dyspnea (236 AHF and 58 non-AHF) and 44 patients with stable chronic heart failure (CHF), and an independent validation cohort of 711 AHF patients, were used. Admission levels of miR-1/-21/-23/-126/-423-5p were assessed in plasma samples.
In the test cohort, admission levels of miR-1 were lower in AHF and stable CHF patients compared to non-AHF patients (p = 0.0016). Levels of miR-126 and miR-423-5p were lower in AHF and in non-AHF patients compared to stable CHF patients (both p |
| doi_str_mv | 10.1371/journal.pone.0142237 |
| format | Article |
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A test cohort of 294 patients with acute dyspnea (236 AHF and 58 non-AHF) and 44 patients with stable chronic heart failure (CHF), and an independent validation cohort of 711 AHF patients, were used. Admission levels of miR-1/-21/-23/-126/-423-5p were assessed in plasma samples.
In the test cohort, admission levels of miR-1 were lower in AHF and stable CHF patients compared to non-AHF patients (p = 0.0016). Levels of miR-126 and miR-423-5p were lower in AHF and in non-AHF patients compared to stable CHF patients (both p<0.001). Interestingly, admission levels of miR-423-5p were lower in patients who were re-admitted to the hospital in the year following the index hospitalization compared to patients who were not (p = 0.0001). Adjusted odds ratio [95% confidence interval] for one-year readmission was 0.70 [0.53-0.93] for miR-423-5p (p = 0.01). In the validation cohort, admission levels of miR-423-5p predicted 1-year mortality with an adjusted odds ratio [95% confidence interval] of 0.54 [0.36-0.82], p = 0.004. Patients within the lowest quartile of miR-423-5p were at high risk of long-term mortality (p = 0.02).
In AHF patients, low circulating levels of miR-423-5p at presentation are associated with a poor long-term outcome. This study supports the value of miR-423-5p as a prognostic biomarker of AHF.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0142237</identifier><identifier>PMID: 26580972</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Aged, 80 and over ; Analysis ; Biomarkers ; Biomarkers - blood ; Biomedical research ; Cancer ; Cardiology ; Cardiovascular disease ; Care and treatment ; Comparative analysis ; Complications and side effects ; Confidence intervals ; Dyspnea ; Dyspnea - blood ; Dyspnea - mortality ; Dyspnea - physiopathology ; Edema ; Emergency medical care ; Female ; Gene expression ; Heart ; Heart diseases ; Heart failure ; Heart Failure - blood ; Heart Failure - mortality ; Heart Failure - physiopathology ; Hospital admission and discharge ; Hospitals ; Humans ; Influence ; Laboratories ; Male ; Medical diagnosis ; Medical research ; MicroRNA ; MicroRNAs ; MicroRNAs - blood ; miRNA ; Mortality ; Patients ; Plasma ; Prognosis ; Respiration ; Risk Factors ; Test procedures</subject><ispartof>PloS one, 2015-11, Vol.10 (11), p.e0142237-e0142237</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Seronde et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Seronde et al 2015 Seronde et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-4e3e8e030525763cea32cfbcbb05eebffbfd6141f206a65a4d48420063bc91993</citedby><cites>FETCH-LOGICAL-c692t-4e3e8e030525763cea32cfbcbb05eebffbfd6141f206a65a4d48420063bc91993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651494/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651494/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26580972$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seronde, Marie-France</creatorcontrib><creatorcontrib>Vausort, Mélanie</creatorcontrib><creatorcontrib>Gayat, Etienne</creatorcontrib><creatorcontrib>Goretti, Emeline</creatorcontrib><creatorcontrib>Ng, Leong L</creatorcontrib><creatorcontrib>Squire, Iain B</creatorcontrib><creatorcontrib>Vodovar, Nicolas</creatorcontrib><creatorcontrib>Sadoune, Malha</creatorcontrib><creatorcontrib>Samuel, Jane-Lise</creatorcontrib><creatorcontrib>Thum, Thomas</creatorcontrib><creatorcontrib>Solal, Alain Cohen</creatorcontrib><creatorcontrib>Laribi, Said</creatorcontrib><creatorcontrib>Plaisance, Patrick</creatorcontrib><creatorcontrib>Wagner, Daniel R</creatorcontrib><creatorcontrib>Mebazaa, Alexandre</creatorcontrib><creatorcontrib>Devaux, Yvan</creatorcontrib><creatorcontrib>GREAT network</creatorcontrib><title>Circulating microRNAs and Outcome in Patients with Acute Heart Failure</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The biomarker value of circulating microRNAs (miRNAs) has been extensively addressed in patients with acute coronary syndrome. However, prognostic performances of miRNAs in patients with acute heart failure (AHF) has received less attention.
A test cohort of 294 patients with acute dyspnea (236 AHF and 58 non-AHF) and 44 patients with stable chronic heart failure (CHF), and an independent validation cohort of 711 AHF patients, were used. Admission levels of miR-1/-21/-23/-126/-423-5p were assessed in plasma samples.
In the test cohort, admission levels of miR-1 were lower in AHF and stable CHF patients compared to non-AHF patients (p = 0.0016). Levels of miR-126 and miR-423-5p were lower in AHF and in non-AHF patients compared to stable CHF patients (both p<0.001). Interestingly, admission levels of miR-423-5p were lower in patients who were re-admitted to the hospital in the year following the index hospitalization compared to patients who were not (p = 0.0001). Adjusted odds ratio [95% confidence interval] for one-year readmission was 0.70 [0.53-0.93] for miR-423-5p (p = 0.01). In the validation cohort, admission levels of miR-423-5p predicted 1-year mortality with an adjusted odds ratio [95% confidence interval] of 0.54 [0.36-0.82], p = 0.004. Patients within the lowest quartile of miR-423-5p were at high risk of long-term mortality (p = 0.02).
In AHF patients, low circulating levels of miR-423-5p at presentation are associated with a poor long-term outcome. This study supports the value of miR-423-5p as a prognostic biomarker of AHF.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Biomedical research</subject><subject>Cancer</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Care and treatment</subject><subject>Comparative analysis</subject><subject>Complications and side effects</subject><subject>Confidence intervals</subject><subject>Dyspnea</subject><subject>Dyspnea - blood</subject><subject>Dyspnea - mortality</subject><subject>Dyspnea - physiopathology</subject><subject>Edema</subject><subject>Emergency medical care</subject><subject>Female</subject><subject>Gene expression</subject><subject>Heart</subject><subject>Heart diseases</subject><subject>Heart failure</subject><subject>Heart Failure - blood</subject><subject>Heart Failure - mortality</subject><subject>Heart Failure - physiopathology</subject><subject>Hospital admission and discharge</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Influence</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical research</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - blood</subject><subject>miRNA</subject><subject>Mortality</subject><subject>Patients</subject><subject>Plasma</subject><subject>Prognosis</subject><subject>Respiration</subject><subject>Risk Factors</subject><subject>Test procedures</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNktuO0zAQhiMEYpeFN0AQCQnBRYtPceIbpKqibKUVRcvh1nKcSevKjbu2w-HtcWl21aC9QL6w5fnmH8_4z7LnGE0xLfG7ret9p-x07zqYIswIoeWD7BwLSiacIPrw5HyWPQlhi1BBK84fZ2eEFxUSJTnPFnPjdW9VNN063xnt3fWnWchV1-SrPmq3g9x0-ecUhy6G_KeJm3ym-wj5JSgf84UytvfwNHvUKhvg2bBfZN8WH77OLydXq4_L-exqorkgccKAQgWIooIUJacaFCW6rXVdowKgbtu6bThmuCWIK14o1rCKEYQ4rbXAQtCL7OVRd29dkMMIgsQlLURBsCgTsTwSjVNbufdmp_xv6ZSRfy-cX8v0bqMtSCF01aC65nWrGYVSUKoELhuKeUOwRknr_VCtr3fQ6DQCr-xIdBzpzEau3Q_JeIGZYEngzSDg3U0PIcqdCRqsVR24fng3ohUlCX31D3p_dwO1VqkB07Uu1dUHUTljlImyFOSgNb2HSquB9MXJL61J96OEt6OExET4FdeqD0Euv1z_P7v6PmZfn7AbUDZugrN9NK4LY5AdwWTAEDy0d0PGSB7sfjsNebC7HOye0l6cftBd0q2_6R8L8vkD</recordid><startdate>20151118</startdate><enddate>20151118</enddate><creator>Seronde, Marie-France</creator><creator>Vausort, Mélanie</creator><creator>Gayat, Etienne</creator><creator>Goretti, Emeline</creator><creator>Ng, Leong L</creator><creator>Squire, Iain B</creator><creator>Vodovar, Nicolas</creator><creator>Sadoune, Malha</creator><creator>Samuel, Jane-Lise</creator><creator>Thum, Thomas</creator><creator>Solal, Alain Cohen</creator><creator>Laribi, Said</creator><creator>Plaisance, Patrick</creator><creator>Wagner, Daniel R</creator><creator>Mebazaa, Alexandre</creator><creator>Devaux, Yvan</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20151118</creationdate><title>Circulating microRNAs and Outcome in Patients with Acute Heart Failure</title><author>Seronde, Marie-France ; Vausort, Mélanie ; Gayat, Etienne ; Goretti, Emeline ; Ng, Leong L ; Squire, Iain B ; Vodovar, Nicolas ; Sadoune, Malha ; Samuel, Jane-Lise ; Thum, Thomas ; Solal, Alain Cohen ; Laribi, Said ; Plaisance, Patrick ; Wagner, Daniel R ; Mebazaa, Alexandre ; Devaux, Yvan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-4e3e8e030525763cea32cfbcbb05eebffbfd6141f206a65a4d48420063bc91993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Biomedical research</topic><topic>Cancer</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Care and treatment</topic><topic>Comparative analysis</topic><topic>Complications and side effects</topic><topic>Confidence intervals</topic><topic>Dyspnea</topic><topic>Dyspnea - blood</topic><topic>Dyspnea - mortality</topic><topic>Dyspnea - physiopathology</topic><topic>Edema</topic><topic>Emergency medical care</topic><topic>Female</topic><topic>Gene expression</topic><topic>Heart</topic><topic>Heart diseases</topic><topic>Heart failure</topic><topic>Heart Failure - blood</topic><topic>Heart Failure - mortality</topic><topic>Heart Failure - physiopathology</topic><topic>Hospital admission and discharge</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Influence</topic><topic>Laboratories</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medical research</topic><topic>MicroRNA</topic><topic>MicroRNAs</topic><topic>MicroRNAs - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seronde, Marie-France</au><au>Vausort, Mélanie</au><au>Gayat, Etienne</au><au>Goretti, Emeline</au><au>Ng, Leong L</au><au>Squire, Iain B</au><au>Vodovar, Nicolas</au><au>Sadoune, Malha</au><au>Samuel, Jane-Lise</au><au>Thum, Thomas</au><au>Solal, Alain Cohen</au><au>Laribi, Said</au><au>Plaisance, Patrick</au><au>Wagner, Daniel R</au><au>Mebazaa, Alexandre</au><au>Devaux, Yvan</au><aucorp>GREAT network</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating microRNAs and Outcome in Patients with Acute Heart Failure</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-11-18</date><risdate>2015</risdate><volume>10</volume><issue>11</issue><spage>e0142237</spage><epage>e0142237</epage><pages>e0142237-e0142237</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The biomarker value of circulating microRNAs (miRNAs) has been extensively addressed in patients with acute coronary syndrome. However, prognostic performances of miRNAs in patients with acute heart failure (AHF) has received less attention.
A test cohort of 294 patients with acute dyspnea (236 AHF and 58 non-AHF) and 44 patients with stable chronic heart failure (CHF), and an independent validation cohort of 711 AHF patients, were used. Admission levels of miR-1/-21/-23/-126/-423-5p were assessed in plasma samples.
In the test cohort, admission levels of miR-1 were lower in AHF and stable CHF patients compared to non-AHF patients (p = 0.0016). Levels of miR-126 and miR-423-5p were lower in AHF and in non-AHF patients compared to stable CHF patients (both p<0.001). Interestingly, admission levels of miR-423-5p were lower in patients who were re-admitted to the hospital in the year following the index hospitalization compared to patients who were not (p = 0.0001). Adjusted odds ratio [95% confidence interval] for one-year readmission was 0.70 [0.53-0.93] for miR-423-5p (p = 0.01). In the validation cohort, admission levels of miR-423-5p predicted 1-year mortality with an adjusted odds ratio [95% confidence interval] of 0.54 [0.36-0.82], p = 0.004. Patients within the lowest quartile of miR-423-5p were at high risk of long-term mortality (p = 0.02).
In AHF patients, low circulating levels of miR-423-5p at presentation are associated with a poor long-term outcome. This study supports the value of miR-423-5p as a prognostic biomarker of AHF.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26580972</pmid><doi>10.1371/journal.pone.0142237</doi><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1735952197 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aged Aged, 80 and over Analysis Biomarkers Biomarkers - blood Biomedical research Cancer Cardiology Cardiovascular disease Care and treatment Comparative analysis Complications and side effects Confidence intervals Dyspnea Dyspnea - blood Dyspnea - mortality Dyspnea - physiopathology Edema Emergency medical care Female Gene expression Heart Heart diseases Heart failure Heart Failure - blood Heart Failure - mortality Heart Failure - physiopathology Hospital admission and discharge Hospitals Humans Influence Laboratories Male Medical diagnosis Medical research MicroRNA MicroRNAs MicroRNAs - blood miRNA Mortality Patients Plasma Prognosis Respiration Risk Factors Test procedures |
| title | Circulating microRNAs and Outcome in Patients with Acute Heart Failure |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T01%3A45%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Circulating%20microRNAs%20and%20Outcome%20in%20Patients%20with%20Acute%20Heart%20Failure&rft.jtitle=PloS%20one&rft.au=Seronde,%20Marie-France&rft.aucorp=GREAT%20network&rft.date=2015-11-18&rft.volume=10&rft.issue=11&rft.spage=e0142237&rft.epage=e0142237&rft.pages=e0142237-e0142237&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0142237&rft_dat=%3Cgale_plos_%3EA434977922%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1735952197&rft_id=info:pmid/26580972&rft_galeid=A434977922&rft_doaj_id=oai_doaj_org_article_99c8d0bb6bfc43e7933a917d316d21c0&rfr_iscdi=true |