Supplementation of Magnolol Attenuates Skeletal Muscle Atrophy in Bladder Cancer-Bearing Mice Undergoing Chemotherapy via Suppression of FoxO3 Activation and Induction of IGF-1

Skeletal muscle atrophy, the most prominent phenotypic feature of cancer cachexia, is often observed in cancer patients undergoing chemotherapy. Magnolol (M) extracted from Magnolia officinalis exhibits several pharmacological effects including anti-inflammatory and anticancer activities. In this st...

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Veröffentlicht in:	PloS one 2015-11, Vol.10 (11), p.e0143594-e0143594
Hauptverfasser:	Chen, Meng-Chuan, Chen, Yen-Lin, Lee, Chi-Feng, Hung, Chih-Huang, Chou, Tz-Chong
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Activin AKT protein Analysis Animals Anticancer properties Atrophy Biphenyl Compounds - therapeutic use Bladder Bladder cancer Body weight Body Weight - drug effects Body weight loss Cachexia Cancer Cancer therapies Care and treatment Chemotherapy Cisplatin Combined treatment Comparative analysis Complications and side effects Cytokines Dietary supplements Enzymatic activity Enzyme activity Enzymes Food intake Forkhead Box Protein O3 Forkhead Transcription Factors - metabolism FOXO3 protein Gemcitabine Health aspects Inflammation Influence Insulin Insulin-like growth factor I Insulin-Like Growth Factor I - metabolism Insulin-like growth factors Interleukin-6 - metabolism Intestine Lignans - therapeutic use Male Medical prognosis Metabolism Mice Mice, Nude Muscles Muscular Atrophy - drug therapy Musculoskeletal system Myostatin NF-kappa B - metabolism NF-κB protein Pharmacology Prevention Preventive medicine Proteasome Endopeptidase Complex - metabolism Proteasomes Protein biosynthesis Protein synthesis Proteins Proteolysis Skeletal muscle Systematic review Transcription Transcription factors Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Ubiquitin Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - metabolism
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