Utility of Metagenomic Next-Generation Sequencing for Characterization of HIV and Human Pegivirus Diversity

Given the dynamic changes in HIV-1 complexity and diversity, next-generation sequencing (NGS) has the potential to revolutionize strategies for effective HIV global surveillance. In this study, we explore the utility of metagenomic NGS to characterize divergent strains of HIV-1 and to simultaneously...

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Veröffentlicht in:	PloS one 2015-11, Vol.10 (11), p.e0141723-e0141723
Hauptverfasser:	Luk, Ka-Cheung, Berg, Michael G, Naccache, Samia N, Kabre, Beniwende, Federman, Scot, Mbanya, Dora, Kaptué, Lazare, Chiu, Charles Y, Brennan, Catherine A, Hackett, Jr, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Analysis Blood Donors Cameroon Coinfection - genetics Drug resistance Epidemics GB virus C - genetics Gene sequencing Genetic aspects Genetic diversity Genetic Variation Genome, Viral Genomes Genomics Genotype Genotypes High-Throughput Nucleotide Sequencing - methods HIV HIV-1 - genetics Human immunodeficiency virus Humans Infections Infectious diseases Laboratories Medical screening Medicine Metagenomics Molecular Sequence Data Phylogeny Population Population studies Recombination, Genetic Risk factors Strains (organisms) Surveillance Viruses
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