TRPM8 Channel Activation Induced by Monoterpenoid Rotundifolone Underlies Mesenteric Artery Relaxation

In this study, our aims were to investigate transient receptor potential melastatin-8 channels (TRPM8) involvement in rotundifolone induced relaxation in the mesenteric artery and to increase the understanding of the role of these thermosensitive TRP channels in vascular tissue. Thus, message and pr...

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Veröffentlicht in:	PloS one 2015-11, Vol.10 (11), p.e0143171-e0143171
Hauptverfasser:	Silva, Darizy Flavia, de Almeida, Monica Moura, Chaves, Cinthia Guedes, Braz, Ana Letícia, Gomes, Maria Aparecida, Pinho-da-Silva, Leidiane, Pesquero, Jorge Luiz, Andrade, Viviane Aguiar, Leite, Maria de Fátima, de Albuquerque, José George Ferreira, Araujo, Islania Giselia Albuquerque, Nunes, Xirley Pereira, Barbosa-Filho, José Maria, Cruz, Jader dos Santos, Correia, Nadja de Azevedo, de Medeiros, Isac Almeida
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arteries Blotting, Western Calcium (intracellular) Calcium - metabolism Calcium Signaling - drug effects Capsaicin Capsaicin - pharmacology Capsaicin receptors Capsazepine Cardiac arrhythmia Channels Cold Cold Temperature Confocal microscopy Cytosol - metabolism Desensitization Endothelium Gene expression In Vitro Techniques Intracellular Ion Channel Gating - drug effects Isometric Laboratory animals Male Menthol Menthol - pharmacology Mesenteric Arteries - drug effects Mesenteric Arteries - physiology Microscopy Monoterpenes - pharmacology Monoterpenoids mRNA Myocytes Natural products Prostate Pyrazines - metabolism Pyridines - metabolism Rats Rats, Sprague-Dawley Real-Time Polymerase Chain Reaction Rodents Ruthenium Ruthenium red Ruthenium Red - metabolism Studies Temperature Transient receptor potential proteins Transients (Dynamics) TRPM Cation Channels - metabolism TRPV Cation Channels - metabolism Vascular tissue Vasodilation Vasodilation - drug effects Vasodilation - physiology Veins & arteries Western blotting
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