Effects of Weight Loss Speed on Kidney Function Differ Depending on Body Mass Index in Nondiabetic Healthy People: A Prospective Cohort
Obesity is associated with diabetes mellitus and cardiovascular diseases. However, it has been reported that weight loss is associated with incident chronic kidney disease (CKD) in healthy males. The purpose of this prospective cohort study is to investigate the effects of weight loss on kidney func...
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| description | Obesity is associated with diabetes mellitus and cardiovascular diseases. However, it has been reported that weight loss is associated with incident chronic kidney disease (CKD) in healthy males. The purpose of this prospective cohort study is to investigate the effects of weight loss on kidney function in healthy people in terms of body mass index (BMI) and gender.
A total of 8447 nondiabetic healthy people were enrolled in the Saitama Cardiometabolic Disease and Organ Impairment Study, Japan. Relationships between estimated glomerular filtration rate (eGFR) change, BMI, and BMI change were evaluated using 3D-scatter plots with spline and generalized additive models (GAMs) adjusted for baseline characteristics.
The subjects were stratified into four groups according to BMI. The mean±standard deviations for males and females were, respectively, 40.11±9.49, and 40.3±9.71 years for age and 76.39±17.72 and 71.49±18.4 ml/min/1.73m2 for eGFR. GAMs showed that a decreasing BMI change ( |
| doi_str_mv | 10.1371/journal.pone.0143434 |
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A total of 8447 nondiabetic healthy people were enrolled in the Saitama Cardiometabolic Disease and Organ Impairment Study, Japan. Relationships between estimated glomerular filtration rate (eGFR) change, BMI, and BMI change were evaluated using 3D-scatter plots with spline and generalized additive models (GAMs) adjusted for baseline characteristics.
The subjects were stratified into four groups according to BMI. The mean±standard deviations for males and females were, respectively, 40.11±9.49, and 40.3±9.71 years for age and 76.39±17.72 and 71.49±18.4 ml/min/1.73m2 for eGFR. GAMs showed that a decreasing BMI change (<-1 kg/m2/year) was associated with a decreasing eGFR change in males with high normal BMIs (22 kg/m2≤BMI<25 kg/m2). A decreasing BMI change (<-2 kg/m2/year) was associated with an increasing eGFR change in overweight males (25 kg/m2≤BMI). Among underweight females (BMI<18.5 kg/m2), decreasing BMI was observed with decreasing eGFR.
These findings suggest that the benefit and risk of weight loss in relation to kidney function differs depending on BMI and weight loss speed, especially in males.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0143434</identifier><identifier>PMID: 26599331</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age ; Age Factors ; Analysis ; Atherosclerosis ; Body mass ; Body Mass Index ; Body size ; Body weight ; Body weight loss ; Cardiovascular diseases ; Care and treatment ; Chronic kidney failure ; Comorbidity ; Complications and side effects ; Demography ; Diabetes ; Diabetes mellitus ; Epidemiology ; Epidermal growth factor receptors ; Female ; Females ; Gastrointestinal surgery ; Gender ; Glomerular Filtration Rate ; Health ; Health promotion ; Health risk assessment ; Heart diseases ; Hospitals ; Humans ; Hypertension ; Kidney - physiology ; Kidney diseases ; Kidney Function Tests ; Male ; Males ; Metabolic disorders ; Metabolic syndrome ; Nephrology ; Obesity ; Overweight ; Prospective Studies ; Risk factors ; Sex differences ; Systematic review ; Underweight ; Weight control ; Weight Loss ; Young adults</subject><ispartof>PloS one, 2015-11, Vol.10 (11), p.e0143434-e0143434</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Kanda et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Kanda et al 2015 Kanda et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-f183d2b4d9aa5da25ee13478972d6a0f772f5e9edce8e36937f00af44578cec43</citedby><cites>FETCH-LOGICAL-c692t-f183d2b4d9aa5da25ee13478972d6a0f772f5e9edce8e36937f00af44578cec43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658128/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658128/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23865,27923,27924,53790,53792,79371,79372</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26599331$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Hribal, Marta Letizia</contributor><creatorcontrib>Kanda, Eiichiro</creatorcontrib><creatorcontrib>Muneyuki, Toshitaka</creatorcontrib><creatorcontrib>Suwa, Kaname</creatorcontrib><creatorcontrib>Nakajima, Kei</creatorcontrib><title>Effects of Weight Loss Speed on Kidney Function Differ Depending on Body Mass Index in Nondiabetic Healthy People: A Prospective Cohort</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Obesity is associated with diabetes mellitus and cardiovascular diseases. However, it has been reported that weight loss is associated with incident chronic kidney disease (CKD) in healthy males. The purpose of this prospective cohort study is to investigate the effects of weight loss on kidney function in healthy people in terms of body mass index (BMI) and gender.
A total of 8447 nondiabetic healthy people were enrolled in the Saitama Cardiometabolic Disease and Organ Impairment Study, Japan. Relationships between estimated glomerular filtration rate (eGFR) change, BMI, and BMI change were evaluated using 3D-scatter plots with spline and generalized additive models (GAMs) adjusted for baseline characteristics.
The subjects were stratified into four groups according to BMI. The mean±standard deviations for males and females were, respectively, 40.11±9.49, and 40.3±9.71 years for age and 76.39±17.72 and 71.49±18.4 ml/min/1.73m2 for eGFR. GAMs showed that a decreasing BMI change (<-1 kg/m2/year) was associated with a decreasing eGFR change in males with high normal BMIs (22 kg/m2≤BMI<25 kg/m2). A decreasing BMI change (<-2 kg/m2/year) was associated with an increasing eGFR change in overweight males (25 kg/m2≤BMI). Among underweight females (BMI<18.5 kg/m2), decreasing BMI was observed with decreasing eGFR.
These findings suggest that the benefit and risk of weight loss in relation to kidney function differs depending on BMI and weight loss speed, especially in males.</description><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Analysis</subject><subject>Atherosclerosis</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Body size</subject><subject>Body weight</subject><subject>Body weight loss</subject><subject>Cardiovascular diseases</subject><subject>Care and treatment</subject><subject>Chronic kidney failure</subject><subject>Comorbidity</subject><subject>Complications and side effects</subject><subject>Demography</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Epidemiology</subject><subject>Epidermal growth factor receptors</subject><subject>Female</subject><subject>Females</subject><subject>Gastrointestinal surgery</subject><subject>Gender</subject><subject>Glomerular Filtration Rate</subject><subject>Health</subject><subject>Health promotion</subject><subject>Health risk assessment</subject><subject>Heart diseases</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Kidney - physiology</subject><subject>Kidney diseases</subject><subject>Kidney Function Tests</subject><subject>Male</subject><subject>Males</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Nephrology</subject><subject>Obesity</subject><subject>Overweight</subject><subject>Prospective Studies</subject><subject>Risk factors</subject><subject>Sex differences</subject><subject>Systematic review</subject><subject>Underweight</subject><subject>Weight control</subject><subject>Weight Loss</subject><subject>Young adults</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk99u0zAUxiMEYmPwBggsISG4aIljx0m4QCrdxioKmxh_Li3HPk5dpXaIk2l9Al4bp-2mFe0C-SKJ_fu-43NyThQ9x_EYkwy_W7q-taIeN87COMaUhPUgOsQFSUYsicnDO-8H0RPvl3Gckpyxx9FBwtKiIAQfRn9OtAbZeeQ0-gWmWnRo7rxHlw2AQs6iz0ZZWKPT3srOhO9jEwQtOoYGrDK2GpiPTq3RFxFkM6vgGhmLvrpwKkrojERnIOpusUYX4Joa3qMJumidb0JYcwVo6hau7Z5Gj7SoPTzbPY-iH6cn36dno_n5p9l0Mh9JViTdSOOcqKSkqhAiVSJJATChWV5kiWIi1lmW6BQKUBJyIKwgmY5joSlNs1yCpOQoern1bWrn-a6GnuOMpIyRLEsDMdsSyoklb1qzEu2aO2H4ZsO1FRdtSKsGTkDkQKXKCqopyKQEWhS4KDFJaSlyFrw-7KL15Wq4lO1aUe-Z7p9Ys-CVu-KUpTlO8mDwZmfQut89-I6vjJdQ18KC6zf3ZiyPCSMBffUPen92O6oSIQFjtQtx5WDKJzRQcYLpEHZ8DxWWgpWRoeG0Cft7grd7gsB0cN1Voveezy6__T97_nOffX2HXWwaybu6H1rR74N0C8rQWr4FfVtkHPNhXm6qwYd54bt5CbIXd3_QrehmQMhfyZQQMw</recordid><startdate>20151123</startdate><enddate>20151123</enddate><creator>Kanda, Eiichiro</creator><creator>Muneyuki, Toshitaka</creator><creator>Suwa, Kaname</creator><creator>Nakajima, Kei</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20151123</creationdate><title>Effects of Weight Loss Speed on Kidney Function Differ Depending on Body Mass Index in Nondiabetic Healthy People: A Prospective Cohort</title><author>Kanda, Eiichiro ; Muneyuki, Toshitaka ; Suwa, Kaname ; Nakajima, Kei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-f183d2b4d9aa5da25ee13478972d6a0f772f5e9edce8e36937f00af44578cec43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Age</topic><topic>Age Factors</topic><topic>Analysis</topic><topic>Atherosclerosis</topic><topic>Body mass</topic><topic>Body Mass Index</topic><topic>Body size</topic><topic>Body weight</topic><topic>Body weight loss</topic><topic>Cardiovascular diseases</topic><topic>Care and treatment</topic><topic>Chronic kidney failure</topic><topic>Comorbidity</topic><topic>Complications and side effects</topic><topic>Demography</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Epidemiology</topic><topic>Epidermal growth factor receptors</topic><topic>Female</topic><topic>Females</topic><topic>Gastrointestinal surgery</topic><topic>Gender</topic><topic>Glomerular Filtration Rate</topic><topic>Health</topic><topic>Health promotion</topic><topic>Health risk assessment</topic><topic>Heart diseases</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Kidney - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kanda, Eiichiro</au><au>Muneyuki, Toshitaka</au><au>Suwa, Kaname</au><au>Nakajima, Kei</au><au>Hribal, Marta Letizia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Weight Loss Speed on Kidney Function Differ Depending on Body Mass Index in Nondiabetic Healthy People: A Prospective Cohort</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-11-23</date><risdate>2015</risdate><volume>10</volume><issue>11</issue><spage>e0143434</spage><epage>e0143434</epage><pages>e0143434-e0143434</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Obesity is associated with diabetes mellitus and cardiovascular diseases. However, it has been reported that weight loss is associated with incident chronic kidney disease (CKD) in healthy males. The purpose of this prospective cohort study is to investigate the effects of weight loss on kidney function in healthy people in terms of body mass index (BMI) and gender.
A total of 8447 nondiabetic healthy people were enrolled in the Saitama Cardiometabolic Disease and Organ Impairment Study, Japan. Relationships between estimated glomerular filtration rate (eGFR) change, BMI, and BMI change were evaluated using 3D-scatter plots with spline and generalized additive models (GAMs) adjusted for baseline characteristics.
The subjects were stratified into four groups according to BMI. The mean±standard deviations for males and females were, respectively, 40.11±9.49, and 40.3±9.71 years for age and 76.39±17.72 and 71.49±18.4 ml/min/1.73m2 for eGFR. GAMs showed that a decreasing BMI change (<-1 kg/m2/year) was associated with a decreasing eGFR change in males with high normal BMIs (22 kg/m2≤BMI<25 kg/m2). A decreasing BMI change (<-2 kg/m2/year) was associated with an increasing eGFR change in overweight males (25 kg/m2≤BMI). Among underweight females (BMI<18.5 kg/m2), decreasing BMI was observed with decreasing eGFR.
These findings suggest that the benefit and risk of weight loss in relation to kidney function differs depending on BMI and weight loss speed, especially in males.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26599331</pmid><doi>10.1371/journal.pone.0143434</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Age Factors Analysis Atherosclerosis Body mass Body Mass Index Body size Body weight Body weight loss Cardiovascular diseases Care and treatment Chronic kidney failure Comorbidity Complications and side effects Demography Diabetes Diabetes mellitus Epidemiology Epidermal growth factor receptors Female Females Gastrointestinal surgery Gender Glomerular Filtration Rate Health Health promotion Health risk assessment Heart diseases Hospitals Humans Hypertension Kidney - physiology Kidney diseases Kidney Function Tests Male Males Metabolic disorders Metabolic syndrome Nephrology Obesity Overweight Prospective Studies Risk factors Sex differences Systematic review Underweight Weight control Weight Loss Young adults |
| title | Effects of Weight Loss Speed on Kidney Function Differ Depending on Body Mass Index in Nondiabetic Healthy People: A Prospective Cohort |
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