Chronic Conductive Hearing Loss Leads to Cochlear Degeneration

Synapses between cochlear nerve terminals and hair cells are the most vulnerable elements in the inner ear in both noise-induced and age-related hearing loss, and this neuropathy is exacerbated in the absence of efferent feedback from the olivocochlear bundle. If age-related loss is dominated by a l...

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Veröffentlicht in:	PloS one 2015-11, Vol.10 (11), p.e0142341-e0142341
Hauptverfasser:	Liberman, M Charles, Liberman, Leslie D, Maison, Stéphane F
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustic noise Acoustic Stimulation Acoustics Age Aging Analysis Animals Auditory plasticity Auditory Threshold Background noise Bundling Care and treatment Cell death Cochlea Cochlea - innervation Cochlea - physiopathology Cochlea - surgery Cochlear Nerve - physiopathology Cochlear Nerve - surgery Comparative analysis Degeneration Disease Models, Animal Ear Ear diseases Ears & hearing Evoked Potentials, Auditory, Brain Stem - physiology Feedback Hair Hair cells Hair Cells, Auditory, Outer - pathology Hearing impairment Hearing loss Hearing Loss, Conductive - physiopathology Hearing Loss, Conductive - surgery Hearing protection Humans Information processing Inner ear Innervation Laboratories Male Medical care Mice Middle age Nerve endings Neuropathy Noise Olivocochlear bundle Otitis media Otitis Media - physiopathology Otitis Media - surgery Otology Physiological aspects Preservation Synapses Synapses - pathology Terminals Tympanic membrane Tympanic Membrane - innervation Tympanic Membrane - physiopathology Tympanic Membrane - surgery United States
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