IL6 Inhibits HBV Transcription by Targeting the Epigenetic Control of the Nuclear cccDNA Minichromosome

The HBV covalently closed circular DNA (cccDNA) is organized as a mini-chromosome in the nuclei of infected hepatocytes by histone and non-histone proteins. Transcription from the cccDNA of the RNA replicative intermediate termed pre-genome (pgRNA), is the critical step for genome amplification and...

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Veröffentlicht in:	PloS one 2015-11, Vol.10 (11), p.e0142599-e0142599
Hauptverfasser:	Palumbo, Gianna Aurora, Scisciani, Cecilia, Pediconi, Natalia, Lupacchini, Leonardo, Alfalate, Dulce, Guerrieri, Francesca, Calvo, Ludovica, Salerno, Debora, Di Cocco, Silvia, Levrero, Massimo, Belloni, Laura
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Binding Cancer therapies Circular DNA Cytokines Deoxyribonucleic acid DNA DNA methylation DNA Methylation - genetics DNA, Circular - genetics DNA, Viral - genetics DNA-Binding Proteins - genetics Epigenesis, Genetic Epigenetics Gene expression Gene Expression Regulation, Viral Genomes Hep G2 Cells Hepatitis Hepatitis B Hepatitis B virus - genetics Hepatitis B virus - pathogenicity Hepatitis B, Chronic - genetics Hepatitis B, Chronic - virology Hepatocyte Nuclear Factor 1-alpha - genetics Hepatocyte Nuclear Factor 4 - genetics Hepatocytes Histones - genetics Humans Infections Inflammation Interleukin 6 Interleukin-6 - genetics Interleukin-6 - metabolism Internal medicine Kinases Liver cancer Medical research Medicine Monomers Nuclei Polyethylene glycol Proteins Replication Ribonucleic acid RNA RNA - genetics Rodents Signal transduction Stat3 protein STAT3 Transcription Factor - genetics Transcription Transcription, Genetic Tumor necrosis factor-α Viral infections Virus Replication - genetics Viruses
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