An Effective Method to Identify Shared Pathways and Common Factors among Neurodegenerative Diseases

Groups of distinct but related diseases often share common symptoms, which suggest likely overlaps in underlying pathogenic mechanisms. Identifying the shared pathways and common factors among those disorders can be expected to deepen our understanding for them and help designing new treatment strat...

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Veröffentlicht in:PloS one 2015-11, Vol.10 (11), p.e0143045-e0143045
Hauptverfasser: Li, Ping, Nie, Yaling, Yu, Jingkai
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description Groups of distinct but related diseases often share common symptoms, which suggest likely overlaps in underlying pathogenic mechanisms. Identifying the shared pathways and common factors among those disorders can be expected to deepen our understanding for them and help designing new treatment strategies effected on those diseases. Neurodegeneration diseases, including Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD), were taken as a case study in this research. Reported susceptibility genes for AD, PD and HD were collected and human protein-protein interaction network (hPPIN) was used to identify biological pathways related to neurodegeneration. 81 KEGG pathways were found to be correlated with neurodegenerative disorders. 36 out of the 81 are human disease pathways, and the remaining ones are involved in miscellaneous human functional pathways. Cancers and infectious diseases are two major subclasses within the disease group. Apoptosis is one of the most significant functional pathways. Most of those pathways found here are actually consistent with prior knowledge of neurodegenerative diseases except two cell communication pathways: adherens and tight junctions. Gene expression analysis showed a high probability that the two pathways were related to neurodegenerative diseases. A combination of common susceptibility genes and hPPIN is an effective method to study shared pathways involved in a group of closely related disorders. Common modules, which might play a bridging role in linking neurodegenerative disorders and the enriched pathways, were identified by clustering analysis. The identified shared pathways and common modules can be expected to yield clues for effective target discovery efforts on neurodegeneration.
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Identifying the shared pathways and common factors among those disorders can be expected to deepen our understanding for them and help designing new treatment strategies effected on those diseases. Neurodegeneration diseases, including Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD), were taken as a case study in this research. Reported susceptibility genes for AD, PD and HD were collected and human protein-protein interaction network (hPPIN) was used to identify biological pathways related to neurodegeneration. 81 KEGG pathways were found to be correlated with neurodegenerative disorders. 36 out of the 81 are human disease pathways, and the remaining ones are involved in miscellaneous human functional pathways. Cancers and infectious diseases are two major subclasses within the disease group. Apoptosis is one of the most significant functional pathways. 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subjects Adherens Junctions - metabolism
Alzheimer Disease - genetics
Alzheimer Disease - metabolism
Alzheimer's disease
Alzheimers disease
Apoptosis
Blood-brain barrier
Cell interactions
Chronic illnesses
Cluster Analysis
Clustering
Cognitive ability
Disorders
Gene expression
Genes
Genetic Predisposition to Disease
Humans
Huntington Disease - genetics
Huntington Disease - metabolism
Huntington's disease
Huntingtons disease
Infectious diseases
Laboratories
Medical treatment
Metabolic Networks and Pathways - genetics
Modules
Movement disorders
Neurodegeneration
Neurodegenerative diseases
Neurological diseases
Neurosciences
Parkinson Disease - genetics
Parkinson Disease - metabolism
Parkinson's disease
Parkinsons disease
Pathways
Probability
Process engineering
Protein interaction
Protein Interaction Maps
Proteins
Tight junctions
Tight Junctions - metabolism
Transcriptome
title An Effective Method to Identify Shared Pathways and Common Factors among Neurodegenerative Diseases
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