Evidence of Selection against Complex Mitotic-Origin Aneuploidy during Preimplantation Development

Whole-chromosome imbalances affect over half of early human embryos and are the leading cause of pregnancy loss. While these errors frequently arise in oocyte meiosis, many such whole-chromosome abnormalities affecting cleavage-stage embryos are the result of chromosome missegregation occurring duri...

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Veröffentlicht in:	PLoS genetics 2015-10, Vol.11 (10), p.e1005601-e1005601
Hauptverfasser:	McCoy, Rajiv C, Demko, Zachary P, Ryan, Allison, Banjevic, Milena, Hill, Matthew, Sigurjonsson, Styrmir, Rabinowitz, Matthew, Petrov, Dmitri A
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Analysis Aneuploidy Biopsy Blastomeres Cell cycle Cell division Chromosome Aberrations Chromosomes Chromosomes - genetics Embryonic Development - genetics Embryos Female Fertility Fertilization in Vitro Generalized linear models Humans In vitro fertilization Mitosis - genetics Pregnancy Preimplantation Diagnosis
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