Essential Role of GATA2 in the Negative Regulation of Type 2 Deiodinase Gene by Liganded Thyroid Hormone Receptor β2 in Thyrotroph

The inhibition of thyrotropin (thyroid stimulating hormone; TSH) by thyroid hormone (T3) and its receptor (TR) is the central mechanism of the hypothalamus-pituitary-thyroid axis. Two transcription factors, GATA2 and Pit-1, determine thyrotroph differentiation and maintain the expression of the β su...

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Veröffentlicht in:	PloS one 2015-11, Vol.10 (11), p.e0142400
Hauptverfasser:	Matsunaga, Hideyuki, Sasaki, Shigekazu, Suzuki, Shingo, Matsushita, Akio, Nakamura, Hirotoshi, Nakamura, Hiroko Misawa, Hirahara, Naoko, Kuroda, Go, Iwaki, Hiroyuki, Ohba, Kenji, Morita, Hiroshi, Oki, Yutaka, Suda, Takafumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiomyocytes Cell Line Cell lines Choriocarcinoma - metabolism Chromatin Chromatin Immunoprecipitation Colforsin - chemistry Endocrinology Forskolin GATA2 Transcription Factor - genetics GATA2 Transcription Factor - physiology GATA4 Transcription Factor - metabolism Gene Deletion Gene expression Gene Expression Regulation Genes Haplorhini Humans Hypothalamus Immunoprecipitation Inhibition Internal medicine Iodide peroxidase Iodide Peroxidase - metabolism Iodothyronine Deiodinase Type II Kinases Ligands Medicine Pit1 protein Pituitary Plasmids Plasmids - metabolism Promoter Regions, Genetic Protein kinase A Proteins Regulatory sequences Response Elements RNA, Messenger - metabolism Signal Transduction Synergism Tethering Thyroid Thyroid gland Thyroid Hormone Receptors beta - metabolism Thyroid-stimulating hormone Thyrotrophs - metabolism Thyrotropin, beta Subunit - metabolism Transcription factors Transcriptional Activation Triiodothyronine Triiodothyronine - metabolism
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