Transforming Growth Factor TGFβ Increases Levels of Microtubule-Associated Protein MAP1S and Autophagy Flux in Pancreatic Ductal Adenocarcinomas

Autophagy is a cellular process to regulate the turnover of misfolded/aggregated proteins or dysfunctional organelles such as damaged mitochondria. Microtubule-associated protein MAP1S (originally named C19ORF5) is a widely-distributed homologue of neuronal-specific MAP1A and MAP1B with which autoph...

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Veröffentlicht in:	PloS one 2015-11, Vol.10 (11), p.e0143150-e0143150
Hauptverfasser:	Song, Kun, Hu, Wei, Yue, Fei, Zou, Jing, Li, Wenjiao, Chen, Qi, Yao, Qizhi, Sun, Weijia, Liu, Leyuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Animals Apoptosis Autophagy Cancer Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Cell cycle Cell death Cell division Cell Line Fluctuations Flux Follow-Up Studies Genomes HeLa Cells Homology Hospitals Humans Liver Liver cancer Markers Medical prognosis Medical research Mice Microtubule-associated protein 1 Microtubule-associated proteins Microtubule-Associated Proteins - antagonists & inhibitors Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Mitochondria Organelles Oxidative stress Pancreatic cancer Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Patients Phagocytosis Prostate Prostate cancer Proteins Real-Time Polymerase Chain Reaction RNA Interference RNA, Small Interfering - metabolism Science Signal transduction Surgery Tissues Transforming growth factor Transforming Growth Factor beta - metabolism Tumor cell lines Tumorigenesis Tumors
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