Analytical Performance Characteristics of the Cepheid GeneXpert Ebola Assay for the Detection of Ebola Virus

The recently developed Xpert® Ebola Assay is a novel nucleic acid amplification test for simplified detection of Ebola virus (EBOV) in whole blood and buccal swab samples. The assay targets sequences in two EBOV genes, lowering the risk for new variants to escape detection in the test. The objective...

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Veröffentlicht in:	PloS one 2015-11, Vol.10 (11), p.e0142216-e0142216
Hauptverfasser:	Pinsky, Benjamin A, Sahoo, Malaya K, Sandlund, Johanna, Kleman, Marika, Kulkarni, Medha, Grufman, Per, Nygren, Malin, Kwiatkowski, Robert, Baron, Ellen Jo, Tenover, Fred, Denison, Blake, Higuchi, Russell, Van Atta, Reuel, Beer, Neil Reginald, Carrillo, Alda Celena, Naraghi-Arani, Pejman, Mire, Chad E, Ranadheera, Charlene, Grolla, Allen, Lagerqvist, Nina, Persing, David H
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Acids Amplification Animals Antigens Assaying Automation Biological and medical sciences Blood Cercopithecus aethiops Deactivation Dynamic stability Ebola virus Ebolavirus Ebolavirus - genetics Ebolavirus - physiology Epidemics Gene sequencing Genes, Viral - genetics Genomes Glycoproteins Hemorrhagic Fever, Ebola - blood Hemorrhagic Fever, Ebola - diagnosis Hemorrhagic Fever, Ebola - virology Host-Pathogen Interactions Humans Inactivation Infectious diseases Laboratories Mass Screening - methods Mathematical analysis Medicine Nucleic Acid Amplification Techniques - methods Nucleic acids Outbreaks Pathogens Pathology Public health Remote monitoring Reproducibility of Results reverse transcriptase-polymerase chain reaction Ribonucleic acid RNA RNA polymerase RNA viruses RNA, Viral - blood RNA, Viral - genetics Sensitivity Sensitivity analysis Sensitivity and Specificity Stability analysis Stability criteria Time Factors Vero Cells Viral diseases viral genomics viral nucleic acid viral replication Virus Inactivation Viruses
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