High PD-L1 Expression Correlates with Metastasis and Poor Prognosis in Oral Squamous Cell Carcinoma

PD-L1 has been widely demonstrated to contribute to failed antitumor immunity. Blockade of PD-L1 with monoclonal antibody could modulate the tumor immune environment to augment immunotherapy. PD-L1 expression is also detected in several types of cancer and is associated with poor prognosis. However,...

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Veröffentlicht in:	PloS one 2015-11, Vol.10 (11), p.e0142656-e0142656
Hauptverfasser:	Lin, Yueh-Min, Sung, Wen-Wei, Hsieh, Ming-Ju, Tsai, Shih-Chen, Lai, Hung-Wen, Yang, Shu-Mei, Shen, Ko-Hong, Chen, Mu-Kuan, Lee, Huei, Yeh, Kun-Tu, Chen, Chih-Jung
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol use Antigens B7-H1 Antigen - biosynthesis Biomarkers Biomarkers, Tumor - biosynthesis Cancer Cancer therapies Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery Chemotherapy Colorectal cancer Community colleges Cytokines Esophageal cancer Female Follow-Up Studies Head & neck cancer Health hazards Health surveillance Hospitals Humans Immunity Immunohistochemistry Immunotherapy Kaplan-Meier Estimate Male Males Medical prognosis Medical technology Medicine Melanoma Metastases Middle Aged Monoclonal antibodies Mortality Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Mouth Neoplasms - surgery Multivariate Analysis Neoplasm Metastasis Nursing Oral cancer Oral squamous cell carcinoma Otolaryngology Outcome Assessment, Health Care - statistics & numerical data Pathology Patients PD-L1 protein Prognosis Proportional Hazards Models Public health Review boards Risk Factors Sex Factors Smoking Squamous cell carcinoma Studies Surgery Tissues Tumors
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