High PD-L1 Expression Correlates with Metastasis and Poor Prognosis in Oral Squamous Cell Carcinoma
PD-L1 has been widely demonstrated to contribute to failed antitumor immunity. Blockade of PD-L1 with monoclonal antibody could modulate the tumor immune environment to augment immunotherapy. PD-L1 expression is also detected in several types of cancer and is associated with poor prognosis. However,...
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| creator | Lin, Yueh-Min Sung, Wen-Wei Hsieh, Ming-Ju Tsai, Shih-Chen Lai, Hung-Wen Yang, Shu-Mei Shen, Ko-Hong Chen, Mu-Kuan Lee, Huei Yeh, Kun-Tu Chen, Chih-Jung |
| description | PD-L1 has been widely demonstrated to contribute to failed antitumor immunity. Blockade of PD-L1 with monoclonal antibody could modulate the tumor immune environment to augment immunotherapy. PD-L1 expression is also detected in several types of cancer and is associated with poor prognosis. However, the prognostic role of PD-L1 in oral squamous cell carcinoma (OSCC) is still controversial. Our aim was to determine the role of PD-L1 in the prognosis of OSCC patients to identify its potential therapeutic relevance. PD-L1 immunoreactivity was analyzed by immunohistochemistry in 305 cancer specimens from primary OSCC patients. The medium follow-up time after surgery was 3.8 years (range from 0.1 to 11.1 years). The prognostic value of PD-L1 on overall survival was determined by Kaplan-Meier analysis and Cox proportional hazard models. Higher PD-L1 expression is more likely in tumor tissues of female than male OSCC patients (P = 0.0062). Patients with distant metastasis also had high PD-L1 expression (P = 0.0103). Multivariate analysis identified high PD-L1 expression as an independent risk factor in males and smokers (males: hazard ratio = 1.556, P = 0.0077; smokers: hazard ratio = 2.058, P = 0.0004). We suggest that PD-L1 expression, determined by IHC staining, could be an independent prognostic marker for OSCC patients who are male or who have a smoking habit. |
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Blockade of PD-L1 with monoclonal antibody could modulate the tumor immune environment to augment immunotherapy. PD-L1 expression is also detected in several types of cancer and is associated with poor prognosis. However, the prognostic role of PD-L1 in oral squamous cell carcinoma (OSCC) is still controversial. Our aim was to determine the role of PD-L1 in the prognosis of OSCC patients to identify its potential therapeutic relevance. PD-L1 immunoreactivity was analyzed by immunohistochemistry in 305 cancer specimens from primary OSCC patients. The medium follow-up time after surgery was 3.8 years (range from 0.1 to 11.1 years). The prognostic value of PD-L1 on overall survival was determined by Kaplan-Meier analysis and Cox proportional hazard models. Higher PD-L1 expression is more likely in tumor tissues of female than male OSCC patients (P = 0.0062). Patients with distant metastasis also had high PD-L1 expression (P = 0.0103). Multivariate analysis identified high PD-L1 expression as an independent risk factor in males and smokers (males: hazard ratio = 1.556, P = 0.0077; smokers: hazard ratio = 2.058, P = 0.0004). We suggest that PD-L1 expression, determined by IHC staining, could be an independent prognostic marker for OSCC patients who are male or who have a smoking habit.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0142656</identifier><identifier>PMID: 26562534</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Alcohol use ; Antigens ; B7-H1 Antigen - biosynthesis ; Biomarkers ; Biomarkers, Tumor - biosynthesis ; Cancer ; Cancer therapies ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - surgery ; Chemotherapy ; Colorectal cancer ; Community colleges ; Cytokines ; Esophageal cancer ; Female ; Follow-Up Studies ; Head & neck cancer ; Health hazards ; Health surveillance ; Hospitals ; Humans ; Immunity ; Immunohistochemistry ; Immunotherapy ; Kaplan-Meier Estimate ; Male ; Males ; Medical prognosis ; Medical technology ; Medicine ; Melanoma ; Metastases ; Middle Aged ; Monoclonal antibodies ; Mortality ; Mouth Neoplasms - metabolism ; Mouth Neoplasms - pathology ; Mouth Neoplasms - surgery ; Multivariate Analysis ; Neoplasm Metastasis ; Nursing ; Oral cancer ; Oral squamous cell carcinoma ; Otolaryngology ; Outcome Assessment, Health Care - statistics & numerical data ; Pathology ; Patients ; PD-L1 protein ; Prognosis ; Proportional Hazards Models ; Public health ; Review boards ; Risk Factors ; Sex Factors ; Smoking ; Squamous cell carcinoma ; Studies ; Surgery ; Tissues ; Tumors</subject><ispartof>PloS one, 2015-11, Vol.10 (11), p.e0142656-e0142656</ispartof><rights>2015 Lin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Lin et al 2015 Lin et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-9ed51816440ec6b2ffb169d1888aa003e32367767aea35f0811c12ad5e3c7cac3</citedby><cites>FETCH-LOGICAL-c526t-9ed51816440ec6b2ffb169d1888aa003e32367767aea35f0811c12ad5e3c7cac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642967/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642967/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26562534$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Yueh-Min</creatorcontrib><creatorcontrib>Sung, Wen-Wei</creatorcontrib><creatorcontrib>Hsieh, Ming-Ju</creatorcontrib><creatorcontrib>Tsai, Shih-Chen</creatorcontrib><creatorcontrib>Lai, Hung-Wen</creatorcontrib><creatorcontrib>Yang, Shu-Mei</creatorcontrib><creatorcontrib>Shen, Ko-Hong</creatorcontrib><creatorcontrib>Chen, Mu-Kuan</creatorcontrib><creatorcontrib>Lee, Huei</creatorcontrib><creatorcontrib>Yeh, Kun-Tu</creatorcontrib><creatorcontrib>Chen, Chih-Jung</creatorcontrib><title>High PD-L1 Expression Correlates with Metastasis and Poor Prognosis in Oral Squamous Cell Carcinoma</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>PD-L1 has been widely demonstrated to contribute to failed antitumor immunity. Blockade of PD-L1 with monoclonal antibody could modulate the tumor immune environment to augment immunotherapy. PD-L1 expression is also detected in several types of cancer and is associated with poor prognosis. However, the prognostic role of PD-L1 in oral squamous cell carcinoma (OSCC) is still controversial. Our aim was to determine the role of PD-L1 in the prognosis of OSCC patients to identify its potential therapeutic relevance. PD-L1 immunoreactivity was analyzed by immunohistochemistry in 305 cancer specimens from primary OSCC patients. The medium follow-up time after surgery was 3.8 years (range from 0.1 to 11.1 years). The prognostic value of PD-L1 on overall survival was determined by Kaplan-Meier analysis and Cox proportional hazard models. Higher PD-L1 expression is more likely in tumor tissues of female than male OSCC patients (P = 0.0062). Patients with distant metastasis also had high PD-L1 expression (P = 0.0103). Multivariate analysis identified high PD-L1 expression as an independent risk factor in males and smokers (males: hazard ratio = 1.556, P = 0.0077; smokers: hazard ratio = 2.058, P = 0.0004). We suggest that PD-L1 expression, determined by IHC staining, could be an independent prognostic marker for OSCC patients who are male or who have a smoking habit.</description><subject>Alcohol use</subject><subject>Antigens</subject><subject>B7-H1 Antigen - biosynthesis</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - biosynthesis</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Chemotherapy</subject><subject>Colorectal cancer</subject><subject>Community colleges</subject><subject>Cytokines</subject><subject>Esophageal cancer</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Head & neck cancer</subject><subject>Health hazards</subject><subject>Health surveillance</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunity</subject><subject>Immunohistochemistry</subject><subject>Immunotherapy</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Males</subject><subject>Medical prognosis</subject><subject>Medical technology</subject><subject>Medicine</subject><subject>Melanoma</subject><subject>Metastases</subject><subject>Middle Aged</subject><subject>Monoclonal antibodies</subject><subject>Mortality</subject><subject>Mouth Neoplasms - metabolism</subject><subject>Mouth Neoplasms - pathology</subject><subject>Mouth Neoplasms - surgery</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Metastasis</subject><subject>Nursing</subject><subject>Oral cancer</subject><subject>Oral squamous cell carcinoma</subject><subject>Otolaryngology</subject><subject>Outcome Assessment, Health Care - statistics & numerical data</subject><subject>Pathology</subject><subject>Patients</subject><subject>PD-L1 protein</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Public health</subject><subject>Review boards</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Smoking</subject><subject>Squamous cell carcinoma</subject><subject>Studies</subject><subject>Surgery</subject><subject>Tissues</subject><subject>Tumors</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptUl2L1DAUDaK46-g_EA344kvHfDVtXwSpq7swsgPqc7hN05kMbTKbtH78e1Onu-yKEEi4Oefcew8HoZeUrCkv6LuDn4KDfn30zqwJFUzm8hE6pxVnmWSEP773PkPPYjwQkvNSyqfobMaynItzpC_tbo-3H7MNxRe_jsHEaL3DtQ_B9DCaiH_acY-_mBFiOjZicC3eeh_wNvid83PJOnwdoMdfbyYY_BRxbfoe1xC0dX6A5-hJB300L5Z7hb5_uvhWX2ab689X9YdNpnMmx6wybU5LKoUgRsuGdV1DZdXSsiwBCOGGMy6LQhZggOcdKSnVlEGbG64LDZqv0OuT7rH3US3-REULzhmhTPCEuDohWg8HdQx2gPBbebDqb8GHnYIwWt0b1UlNiU69SdEJyjQYA1BWpKFVU0ASW6H3S7epGUyrjRuTBw9EH_44u1c7_0MJKVgliyTwdhEI_mYycVSDjTo5B84kE-e5BSsZYWWCvvkH-v_txAmlg48xmO5uGErUnJlblpozo5bMJNqr-4vckW5Dwv8ATaO_YQ</recordid><startdate>20151112</startdate><enddate>20151112</enddate><creator>Lin, Yueh-Min</creator><creator>Sung, Wen-Wei</creator><creator>Hsieh, Ming-Ju</creator><creator>Tsai, Shih-Chen</creator><creator>Lai, Hung-Wen</creator><creator>Yang, Shu-Mei</creator><creator>Shen, Ko-Hong</creator><creator>Chen, Mu-Kuan</creator><creator>Lee, Huei</creator><creator>Yeh, Kun-Tu</creator><creator>Chen, Chih-Jung</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20151112</creationdate><title>High PD-L1 Expression Correlates with Metastasis and Poor Prognosis in Oral Squamous Cell Carcinoma</title><author>Lin, Yueh-Min ; Sung, Wen-Wei ; Hsieh, Ming-Ju ; Tsai, Shih-Chen ; Lai, Hung-Wen ; Yang, Shu-Mei ; Shen, Ko-Hong ; Chen, Mu-Kuan ; Lee, Huei ; Yeh, Kun-Tu ; Chen, Chih-Jung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-9ed51816440ec6b2ffb169d1888aa003e32367767aea35f0811c12ad5e3c7cac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Alcohol use</topic><topic>Antigens</topic><topic>B7-H1 Antigen - biosynthesis</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - biosynthesis</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Chemotherapy</topic><topic>Colorectal cancer</topic><topic>Community colleges</topic><topic>Cytokines</topic><topic>Esophageal cancer</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Head & neck cancer</topic><topic>Health hazards</topic><topic>Health surveillance</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Immunity</topic><topic>Immunohistochemistry</topic><topic>Immunotherapy</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Males</topic><topic>Medical prognosis</topic><topic>Medical technology</topic><topic>Medicine</topic><topic>Melanoma</topic><topic>Metastases</topic><topic>Middle Aged</topic><topic>Monoclonal antibodies</topic><topic>Mortality</topic><topic>Mouth Neoplasms - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Yueh-Min</au><au>Sung, Wen-Wei</au><au>Hsieh, Ming-Ju</au><au>Tsai, Shih-Chen</au><au>Lai, Hung-Wen</au><au>Yang, Shu-Mei</au><au>Shen, Ko-Hong</au><au>Chen, Mu-Kuan</au><au>Lee, Huei</au><au>Yeh, Kun-Tu</au><au>Chen, Chih-Jung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High PD-L1 Expression Correlates with Metastasis and Poor Prognosis in Oral Squamous Cell Carcinoma</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-11-12</date><risdate>2015</risdate><volume>10</volume><issue>11</issue><spage>e0142656</spage><epage>e0142656</epage><pages>e0142656-e0142656</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>PD-L1 has been widely demonstrated to contribute to failed antitumor immunity. Blockade of PD-L1 with monoclonal antibody could modulate the tumor immune environment to augment immunotherapy. PD-L1 expression is also detected in several types of cancer and is associated with poor prognosis. However, the prognostic role of PD-L1 in oral squamous cell carcinoma (OSCC) is still controversial. Our aim was to determine the role of PD-L1 in the prognosis of OSCC patients to identify its potential therapeutic relevance. PD-L1 immunoreactivity was analyzed by immunohistochemistry in 305 cancer specimens from primary OSCC patients. The medium follow-up time after surgery was 3.8 years (range from 0.1 to 11.1 years). The prognostic value of PD-L1 on overall survival was determined by Kaplan-Meier analysis and Cox proportional hazard models. Higher PD-L1 expression is more likely in tumor tissues of female than male OSCC patients (P = 0.0062). Patients with distant metastasis also had high PD-L1 expression (P = 0.0103). Multivariate analysis identified high PD-L1 expression as an independent risk factor in males and smokers (males: hazard ratio = 1.556, P = 0.0077; smokers: hazard ratio = 2.058, P = 0.0004). We suggest that PD-L1 expression, determined by IHC staining, could be an independent prognostic marker for OSCC patients who are male or who have a smoking habit.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26562534</pmid><doi>10.1371/journal.pone.0142656</doi><oa>free_for_read</oa></addata></record> |
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| source | Public Library of Science (PLoS) Journals Open Access; PubMed (Medline); MEDLINE; DOAJ Directory of Open Access Journals; Free E-Journal (出版社公開部分のみ）; Free Full-Text Journals in Chemistry |
| subjects | Alcohol use Antigens B7-H1 Antigen - biosynthesis Biomarkers Biomarkers, Tumor - biosynthesis Cancer Cancer therapies Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery Chemotherapy Colorectal cancer Community colleges Cytokines Esophageal cancer Female Follow-Up Studies Head & neck cancer Health hazards Health surveillance Hospitals Humans Immunity Immunohistochemistry Immunotherapy Kaplan-Meier Estimate Male Males Medical prognosis Medical technology Medicine Melanoma Metastases Middle Aged Monoclonal antibodies Mortality Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Mouth Neoplasms - surgery Multivariate Analysis Neoplasm Metastasis Nursing Oral cancer Oral squamous cell carcinoma Otolaryngology Outcome Assessment, Health Care - statistics & numerical data Pathology Patients PD-L1 protein Prognosis Proportional Hazards Models Public health Review boards Risk Factors Sex Factors Smoking Squamous cell carcinoma Studies Surgery Tissues Tumors |
| title | High PD-L1 Expression Correlates with Metastasis and Poor Prognosis in Oral Squamous Cell Carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T14%3A45%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=High%20PD-L1%20Expression%20Correlates%20with%20Metastasis%20and%20Poor%20Prognosis%20in%20Oral%20Squamous%20Cell%20Carcinoma&rft.jtitle=PloS%20one&rft.au=Lin,%20Yueh-Min&rft.date=2015-11-12&rft.volume=10&rft.issue=11&rft.spage=e0142656&rft.epage=e0142656&rft.pages=e0142656-e0142656&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0142656&rft_dat=%3Cproquest_plos_%3E3867198191%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1733201243&rft_id=info:pmid/26562534&rft_doaj_id=oai_doaj_org_article_f6c10c88807f412caeeaa890b19b7a24&rfr_iscdi=true |